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| Research progress of Wnt/LRP6 signaling pathway on synaptic function in alzheimer′s Disease |
| WANG Su1 LI Yiping1 XIE Ning2 |
1.Graduate College, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Basic Medical College, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Alzheimer′s disease (AD) is one of the most common dementias currently. AD is characterized by the formation of senile plaques by the deposition of β amyloid in the brain, and the main pathological manifestations of neurofibrillary tangles and loss of neurons caused by excessive phosphorylation of Tau protein, accompanied by neuroinflammatory changes and cognitive impairment. There have been extensive studies to prove that synaptic dysfunction and synaptic loss are pathological manifestations of AD in the early stage. Aβ has direct toxic effect on the synapse, but the type of signaling pathway through which Aβ affects the synapse needs further study. The Wnt/β-catenin signaling pathway plays an important role in the functional and morphological integrity of synaptic connections in the adult brain through the common wnt-lrp6 locus. On this basis, this paper explores the underlying mechanism of AD susceptibility in order to reveal new therapeutic targets and methods.
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