川芎嗪对血管内皮损伤的保护作用机制研究进展

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Abstract The degree of vascular endothelial injury is closely related to the development of cardiovascular diseases such as hypertension. Many kinds of cardiovascular diseases, such as hypertension, coronary heart disease and atherosclerosis, will present different degrees of vascular endothelial injury, and the protection of injured endothelial cells is the key to the prevention and treatment of cardiovascular diseases. Tetramethylpyrazine is a kind of alkaloid extracted from Chinese herbal medicine Ligusticum chuanxiong Hort.. It has biological activity and many pharmacological effects. Its pharmacological effects include, delaying endothelial cell apoptosis, promoting angiogenesis, anti-inflammatory, antioxidant, etc. It can be used to treat the changes in vascular structure and function caused by hypertension. This article reviews the research progress of Tetramethylpyrazine against vascular endothelial injury in hypertension, and provides scientific basis for the clinical application of Tetramethylpyrazine in the treatment of cardiovascular and cerebrovascular diseases.

Key words： Tetramethylpyrazine Vascular endothelial injury Angiogenesis Oxidative stress

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	LI Fangfang ZHANG Qi

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LI Fangfang ZHANG Qi. Advance in studies on the protective effect of Tetramethylpyrazine on vascular endothelial injury[J]. 中国医药导报, 2020, 17(8): 25-28.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I8/25

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