类叶升麻苷对APP/PS1双转基因小鼠行为学和激素变化的影响

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (809 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effects of acteoside on behavior and hormone changes of APP/PS1 double transgenic mice. Methods Ten mice of C57 BL/6J were selected as control (group A). 50 healthy APP/PS1 double transgenic mice were randomly divided into group B (model), group C (Donepezil), group D (low dose of acteoside), group E (medium dose of acteoside), group F (high dose of acteoside), 10 mice in each group. After 120 days of continuous administration, O maze test was carried out, and Aβ1-40 content in hippocampus of mice and the hormone content in serum and pituitary gland were determined. Results Compared with group A, the distance and time of arm opening in group B were significantly shortened (P < 0.05); compared with group B, the distance and time of arm opening in group D were significantly lengthened (P < 0.01), and the distance of arm opening in group E was lengthened (P < 0.05). Compared with group A, the content of Aβ1-40 in group B increased significantly (P < 0.01); compared with group B, the content of Aβ1-40 in group E decreased significantly (P < 0.01). Compared with group A, the content of adrenocorticotropic hormone in group B was significantly increased (P < 0.05); compared with group B, the content of adrenocorticotropic hormone in group C and group F was significantly decreased, and the content of cortisol in group F was significantly decreased (P < 0.05). Compared with group B, follicle-stimulating hormone content in pituitary gland of group D decreased significantly (P < 0.05). Compared with group A, thyroid-stimulating hormone content of group B was significantly decreased (P < 0.05); compared with group B, thyroid-stimulating hormone content of group C, group E and group F was significantly increased (P < 0.05 or P < 0.01). Compared with group A, growth hormone content in pituitary of group B decreased significantly (P < 0.05); compared with group B, growth hormone content of group C, group E and group F increased significantly (P < 0.05 or P < 0.01). Conclusion Acteoside can improve the anxiety emotion of APP/PS1 double transgenic mice, protect the cerebral neural circuit and improve the memory ability by regulating the content of Aβ1-40 and the hormone secretion.

Key words： Acteoside Alzheimer disease Behavioristics Hormonal change

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Jiayuan1 GAO Li2 LUO Jianan2 LI Jianmei2 YAN Ming2▲

Cite this article:

CHEN Jiayuan1 GAO Li2 LUO Jianan2 LI Jianmei2 YAN Ming2▲. Effects of acteoside on behavior and hormone changes of APP/PS1 double transgenic mice[J]. 中国医药导报, 2020, 17(8): 9-12.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I8/9

[1] 谢玉婷，高雪峰，董贵成，等.阿尔兹海默病致病机制及新型治疗药物研究进展[J].生物化工，2018，4（6）：116-119.
[2] 刘铮，魏成喜.阿尔兹海默症的发病机制探究[J].世界最新医学信息文摘，2019，19（8）：170-171.
[3] Song IU，Kim YD，Chung SW，et al. Association between serum haptoglobin and the pathogenesis of Alzheimerˊs disease [J]. Internal Med，2015，54（5）：453-457.
[4] Swaab D，Bao AM，Lucassen PJ. The stress system in the human brain in depression and neurodegeneration [J]. Ageing Res Rev，2005，4（2）：141-194.
[5] 谭雪，高莉，任佳，等.类叶升麻苷对东莨菪碱致小鼠学习记忆障碍的改善作用[J].中国新药杂志，2018，27（23）：2812-2818.
[6] 罗嘉楠，马丁丁，黄晏，等.类叶升麻苷对APP/PS1双转基因小鼠行为学和抗氧化能力的影响[J].中药药理与临床，2016，32（6）：56-60.
[7] 罗嘉楠.AE-624对APP/PS1转基因模型小鼠认知行为的影响及其机制研究[D].乌鲁木齐：新疆医科大学，2017.
[8] 罗嘉楠，高莉，黄晏，等.类叶升麻苷对β-淀粉样蛋白聚集影响的体外研究[J].新疆医科大学学报，2017，40（2）：220-223，228.
[9] 马丁丁，黄晏，李栋，等.类叶升麻苷对STZ侧脑室注射模型小鼠认知行为及LTP的影响[J].新疆医科大学学报，2017，40（3）：328-333.
[10] 高莉，彭晓明，霍仕霞，等.类叶升麻苷增强致亚急性衰老小鼠脑组织神经营养因子3的表达[J].细胞与分子免疫学杂志，2014，30（10）：1022-1025，1029.
[11] Calleo JS，Kunik ME，Reid D，et al. Characteristics of generalized anxiety disorder in patients with dementia [J]. Am J Alzheimers Dis，2011，26（6）：492-497.
[12] 万朋，高俊涛，刘志洋，等.部分学习记忆的行为学方法研究及其应用[J].吉林医药学院学报，2015，36（1）：57-60.
[13] 敖鹏，边晓燕，费洪新，等.通天草提取物对Aβ1-40所致老年痴呆大鼠基底核超微结构影响[J].中医药学报，2017，45（2）：19-22.
[14] 温世荣，于艳红，王德生，等.凋亡相关蛋白在阿尔茨海默病病理改变中的作用[J].中国医药导报，2019，16（25）：16-19.
[15] Canet G，Hernandez C，Zussy C，et al. Is AD a stress-related disorder? Focus on the HPA axis and its promising therapeutic targets [J]. Front Aging Neurosci，2019，11（9）：269.
[16] Reilly EB，Gunnar MR. Neglect，HPA axis reactivity，and development [J]. Int J Dev Neurosci，2019，78：100-108.
[17] Cherian K，Schatzberg AF，Keller J. HPA axis in psychotic major depression and schizophrenia spectrum disorders：cortisol，clinical symptomatology，and cognition [J]. Schizophr Res，2019，213：72-79.
[18] Qassemian A，Koushkie Jahromi M，Salesi M，et al. Swimming modifies the effect of noise stress on the HPG axis of male rats [J]. Hormones，2019，18（4）：417-422.
[19] 周晓辉，韩晶.甲状腺激素与老年痴呆的关系[J].中国康复理论与实践，2008，14（1）：46-48.
[20] 左卫星，张志飞，刘志民，等.参与下丘脑-垂体-甲状腺轴负反馈调控的分子元件研究进展[J].生物技术进展，2017，7（6）：601-607.
[21] 石清兰，毛德文，陈月桥，等.解毒化瘀Ⅱ方对HBV相关急性肝衰竭患者外周血Th17、Th1表达及临床疗效的影响[J].中国医药导报，2018，15（21）：122-125.