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| Diagnostic value of serum amyloid A in Mycoplasma pneumoniae pneumonia |
| XIAN Xiaoying DING Yanling▲ |
| Department of Clinical Laboratory, Liuzhou Maternal and Child Healthcare Hospital, Guangxi Zhuang Automous Region, Liuzhou 545000, China |
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Abstract Objective To investigate the diagnostic value of serum amyloid A protein (SAA) in Mycoplasma pneumoniae pneumonia (MPP). Methods A total of 130 children with MPP who came to the pediatric inpatient department of Liuzhou Maternal and Child Healthcare Hospital (hereinafter referred to as “our hospital”) from march to June 2019 were collected as the MPP group, and 100 healthy children who underwent physical examination in the child healthcare department of our hospital during the same period were selected as the control group. The levels of SAA, C-reactive protein (CRP), white blood cell (WBC) in whole blood and serum creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (HBDH) were compared between the two groups. The correlation between SAA and other indicators in MPP group was analyzed, and the diagnostic efficacy of SAA, CRP and WBC on MPP was analyzed by ROC curve. Results The levels of SAA, CRP and WBC in MPP group were higher than those in control group, with statistically significant differences (all P ＜ 0.05). SAA was positively correlated with CRP and WBC (r = 0.760, 0.369, P ＜ 0.05). There was no correlation between SAA, CK, CK-MB, LDH and HBDH (P ＞ 0.05). The ROC curve of MPP was drawn with SAA, CRP and WBC as variables. The area under the ROC curve was 0.942, 0.689 and 0.618, respectively. The sensitivity of MPP was 81.2%, 75.4% and 56.2%, and the specificity was 90.3%, 93.0% and 63.0%, respectively. Conclusion SAA level detection can be used as the monitoring index of MPP and is of great significance to the auxiliary diagnosis of MPP.
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