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| Effect of adjuvant treatment with modified Shaoyao Gancao Decoction on pain mediators and inflammatory factors in patients with cancer pain |
| CAO Di1 ZHANG Yami2 |
1.Department of the First Clinical Medicine, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712000, China;
2.the Second Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712021, China |
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Abstract Objective To investigate the effects of adjuvant treatment with modified Shaoyao Gancao Decoction on pain mediators and inflammatory factors in patients with cancer pain. Methods One hundred and twenty-three patients with cancer pain admitted to Affiliated Hospital of Shaanxi University of Chinese Medicine from October 2017 to March 2019 were selected and divided into control group (n = 61) and study group (n = 62) according to random number table method. The patients in control group were treated with Morphine Sulfate Sustained-Release Tablets. The patients in study group were treated with modified Shaoyao Gancao Decoction on the basis of control group. The course of treatment was 4 weeks. Clinical efficacy, pain mediators (5-HT, PGE2, SP, ET-1) and inflammatory factors (IL-1β, IL-6, TNF-α) were compared between two groups. Adverse reactions during treatment were recorded in two groups. Results Total clinical effective rate of study group after treatment was significantly higher than that of control group (P < 0.05). After treatment, the levels of 5-HT, PGE2, SP and ET-1 in two groups were lower than those before treatment, and the levels in study group were lower than those in control group (P < 0.05). After treatment, the levels of IL-1β, IL-6 and TNF-α in two groups were lower than those before treatment, and the levels in study group were lower than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Modified Shaoyao Gancao Decoction can effectively improve the level of pain mediators and inflammatory factors in patients with cancer pain. It has definite curative effect and does not increase the incidence of adverse reactions. It has certain clinical application value.
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