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| A meta-analysis of the effects of blood transfusion on the prognosis of patients undergoing gastric cancer surgery |
| KELIMU·Gulipari1 ZHANG Lei▲ |
| Department of Anesthesia, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China |
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Abstract Objective To evaluate affects about perioperative allogenenic blood transfusion (ABT) on the prognosis of patients with gastric cancer surgery. Methods PubMed, Cochrane Library, EMBASE, and Highwire biomedical databases were retrieved by computer, and clinical controlled trials from January 2000 to January 2019 to study the effect of perioperative ABT on the prognosis of patients with gastric cancer surgery were collected. A meta-analysis was performed using Stata version 12.0 software to systematically evaluate the effects of perioperative ABT on 5-year survival, tumor recurrence, and postoperative complications. Results A total of 20 high-quality related literatures were included. Compared with the non-transfusion group, the 5-year survival rate of patients in the ABT group was reduced (OR = 0.47, 95%CI: 0.39-0.56, P = 0.005), while the tumor recurrence rates (OR = 2.09, 95%CI: 1.35-3.25, P = 0.000) and the incidence of postoperative complications were increased (OR = 2.40, 95%CI: 1.81-3.19, P = 0.000), and the differences were statistically significant. Conclusion Perioperative ABT can adversely affect the prognosis of patients with gastric cancer surgery.
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