大气细颗粒物污染与慢性阻塞性肺疾病气道炎症和氧化应激关系研究

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Abstract Objective To investigate the relationship between air fine particulate matter (PM2.5) pollution and airway inflammation and oxidative stress in patients with chronic obstructive pulmonary disease (COPD). Methods Eighty patients with chronic obstructive pulmonary disease who admitted to the Jiyang People′s Hospital of Ji′nan City Shandong Province (“our hospital” for short from) May 2018 to May 2019 were divided into the urban group (40 cases) and the suburban group (40 cases) according to the living area of the patients. In the same period, 40 patients who were included in our hospital for healthy physical examination were established as the control group. The real-time monitoring data of PM2.5 in the living environment of the subjects were continuously monitored for 12 weeks, and the forced expiratory volume in the first second (FEV1), the proportion of forced expiratory volume in the first second (FEV1/FVC%), serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels of the subjects in the three groups were compared and analyzed. Results PM2.5 particles monitored in the urban group for 12 weeks were significantly higher than those in the suburban group, and the differences were statistically significant (P ＜ 0.05). FEV1 and FEV1/FVC% in the urban group and the suburban group were lower than those in the control group (P ＜ 0.05). There was no significant difference in FEV1, FEV1/FVC%, MDA and SOD between the urban group and the suburban group (P > 0.05). MDA concentration in the suburban group was lower than that in the urban group and was higher than that in the control group (P ＜ 0.05). There was no significant difference in SOD level between the three groups (P ＞ 0.05). PM2.5 was negatively correlated with FEV1, FEV1/FVC% in COPD patients (r = -0.428, -0.807, P ＜ 0.05). PM2.5 was positively correlated with SOD and MDA in COPD patients (r = 0.543, 0.502, P ＜ 0.05). Conclusion High levels of PM2.5 exposure may reduce lung function in patients with COPD, increase airway inflammation and oxidative stress, and aggravate the disease. In this regard, the prevention of haze weather should be done to protect the health of the residents and avoid the adverse effects of PM2.5 on the human body.

Key words： Atmospheric fine particulate pollution Chronic obstructive pulmonary disease Airway inflammation Oxidative stress

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	ZHOU Wei1
	2 JIANG Shujuan3

Cite this article:

ZHOU Wei1,2 JIANG Shujuan3. Relationship between fine particulate matter pollution and airway inflammation and oxidative stress in chronic obstructive pulmonary disease[J]. 中国医药导报, 2020, 17(5): 125-128.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I5/125

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