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| Correlation between serum level of GDF-15 and pulmonary artery pressure in patients with chronic obstructive pulmonary disease |
| ZHANG Juan1 YANG Heyin2 HU Yuying2 WANG Huaizhen1 |
1.Department of Respiratory Medicine, the First People′s Hospital of Kashgar, Xinjiang Uygur Autonomous Region, Kashgar 844000, China;
2.Department of Cardiology, the First People′s Hospital of Kashgar, Xinjiang Uygur Autonomous Region, Kashgar 844000, China |
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Abstract Objective To investigate the correlation between serum level of growth differentiation factor-15 (GDF-15) and pulmonary artery pressure in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 112 patients with COPD admitted to First People′s Hospital of Kashgar (“our hospital” for short) from January 2016 to January 2019 were selected as the study group. According to whether have hypertension or not, the patients were divided into non-pulmonary hypertension group (36 cases) and combined pulmonary hypertension group (76 cases). The patients combined pulmonary hypertension were divided into mild group (24 cases), moderate group (31 cases) and severe group (21 cases) according to pulmonary systolic pressure (sPAP). A total of 60 healthy people from our hospital during the same period were selected as the control group. The serum levels of GDF-15 and brain natriuretic peptide (BNP) were detected, while the correlation between serum levels GDF-15 and sPAP and BNP were analyzed. Results Serum GDF-15 and BNP levels in the non-pulmonary hypertension group and the combined pulmonary hypertension group were significantly higher than those in the control group, and the combined pulmonary hypertension group was significantly higher than the non-pulmonary hypertension group (P ＜ 0.05). The levels of serum sPAP, GDF-15 and BNP in the moderate and severe groups were significantly higher than those in the mild group, and the severe group was higher than the moderate group (P ＜ 0.05). The serum GDF-15 levels were positively correlated with sPAP and BNP in COPD patients (r = 0.507, 0.350, P = 0.001, 0.029). Conclusion GDF-15 is significantly increased in the serum of COPD patients combined pulmonary hypertension, and it is positively correlated with sPAP and BNP.
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