孕晚期血清25羟基维生素D3水平及环境因素对早期婴儿湿疹的预测作用

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Abstract Objective To explore the predictive value of 25 hydroxyvitamin D3 [25(OH)D3] and environmental risk factors for infantile eczema. Methods From January to December 2016, 528 pregnant women who gave birth regularly in the obstetrical clinic of the People′s Hospital of Xinjiang Uygur Autonomous Region were selected as a cohort. Serums 25(OH)D3 levels of pregnant women were measured, and infants were followed up for 6 months to observe the occurrence of infant eczema, the predictive value of 25(OH)D3 for infants eczema was analyzed. Results Finally, 505 pairs of mothers and infants completed, 243 cases (48.1%) of the infants were diagnosed with eczema, of which eczema of 56.4% (137/243) infants occurred from 2 to 3 months after birth. According to the occurrence of eczema, the infants were divided into eczema group (n = 243) and control group (n = 262). The maternal 25(OH)D3 in eczema group was lower than control group (P < 0.05). The results of ROC analysis showed that the area under curve was 0.584, the sensitivity was 90.70%, the specificity was 14.17%, the positive predictive value was 50.18%, the negative predictive value was 61.52%. Therefore, the diagnostic value of maternal 25(OH)D3 in the third trimester of pregnancy was low. Logistic regression analysis showed that the positive maternal allergy history (OR = 8.308, 95%CI: 5.131-13.45), cesarean section delivery (OR = 1.494, 95%CI: 0.977-2.286), frequent passive smoking during pregnancy (OR = 1.386, 95%CI: 0.680-4.826) were the risk factors of infant eczema (P < 0.05); but compared with 25(OH)D3 deficiency, low 25(OH)D3 (OR = 0.233, 95%CI: 0.138-0.392) and high 25(OH)D3 (OR = 0.459, 95%CI: 0.270-0.779) in late pregnancy were the protect factors of infant eczema (P < 0.05). Conclusion There is a low predictive value of serum 25(OH)D3 in infantile eczema.

Key words： Eczema infants Pregnancy Environmental factors 25 hydroxyvitamin D3

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	LI Xiaorui1 WANG Xinchun1 ZHU Lihong2

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LI Xiaorui1 WANG Xinchun1 ZHU Lihong2. Predictive value of third trimester of pregnancy serum 25(OH)D3 and environmental risk factors for infantile eczema[J]. 中国医药导报, 2020, 17(5): 87-90,94.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I5/87

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