自拟养心饮辅助西药治疗冠状动脉粥样硬化性心脏病心绞痛的效果

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Abstract Objective To explore the effects of self-made Yangxin Drink assisted with Western medicine in the treatment of angina pectoris of coronary heart disease (CHD) and the influence on angina pectoris symptoms, peripheral blood lipids, apolipoprotein B/A1 (ApoB/A1) ratio, N-terminal pro-brain natriuretic peptide (NT-pro-BNP), thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α). Methods A total of 140 patients with angina pectoris of CHD in Qinhuangdao Muncipality Traditional Chinese Medicine Hospital of Hebei Province from February 2016 to April 2017 were selected and divided into traditional Western medicine group and Yangxin Drink group according to the random number table method by 1∶1 ratio, with 70 cases in each group. Traditional Western medicine group was given symptomatic treatment with traditional Western medicine, and Yangxin Drink group was given oral therapy of self-made Yangxin Drink based on the above treatment. After 1 month of treatment, traditional Chinese medicine syndrome scores and efficacy of traditional Chinese medicine syndrome were evaluated before and after treatment, and the angina pectoris attack, cardiac function indexes, ApoB/A1 and plasma NT-pro-BNP, TXB2 and 6-keto-PGF1α were compared before and after treatment. Results After treatment, traditional Chinese medicine syndrome score of two groups was significantly lower than that before treatment, and Yangxin Drink group was lower than that traditional Western medicine group (P < 0.05). Total effective rate of traditional Chinese medicine syndrome in Yangxin Drink group was significantly higher than that in traditional Western medicine group (P < 0.05). After treatment, the number of angina pectoris attacks and myocardial oxygen consumption in two groups were significantly reduced, the duration of angina pectoris attack was significantly shorter than before treatment, and LVDD and LVEF were significantly lower than before treatment (P < 0.05), the changes of the above indexes in Yangxin Drink group were significantly larger than those in traditional Western medicine group (P < 0.05). After treatment, the levels of ApoB/A1, NT-pro-BNP and TXB2 in two groups were significantly lower than before treatment, and the level of 6-keto-PGF1α was significantly higher than before treatment (P < 0.05), change range of Yangxin Drink group was significantly larger than that of traditional Western medicine group (P < 0.05). Conclusion Self-made Yangxin Drink assisted with Western medicine has exact efficacy in the treatment of patients with angina pectoris of CHD, and it can significantly alleviate the angina pectoris-related symptoms, improve the angina pectoris attack, cardiac function damage and vascular endothelial dysfunction, and reduce the risk of atherosclerosis.

Key words： Self-made Yangxin Drink Angina pectoris symptoms Apolipoprotein B/A1 ratio Vascular endothelial function

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	WANG Haitao HUANG Chunli ZHAI Yaoyao

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WANG Haitao HUANG Chunli ZHAI Yaoyao. Effects of self-made Yangxin Drink assisted with Western medicine in the treatment of angina pectoris of coronary atherosclerotic heart disease[J]. 中国医药导报, 2020, 17(5): 63-66.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I5/63

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