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| Research progress of aldehyde dehydrogenase 2 in Alzheimer′s disease |
| LIU Haitao GE Wei |
| Department of Geriatrics, the First Affiliated Hospital of Air Force Medical University, Shaanxi Province, Xi′an 710032, China |
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Abstract Alzheimer′s disease (AD) is a chronic, progressive neurodegenerative disease, and oxidative stress injury and toxic aldehydes deposition play an important role in AD pathology. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is an aldehyde oxidation-reduction enzyme. ALDH2 activity is determined by its genotype. Carriers of ALDH2 mutation have a higher risk of suffering AD. Basic studies suggest that ALDH2 can reduce the deposition of 4-HNE produced by oxidative stress in important organs, especially brain tissues, thereby reducing the oxidative stress injury of neuronal cells. This article will review the research progress of ALDH2 in AD, and provide novel insights for disease prevention and control.
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