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| Clinical effect of Kuncao Qilian Decoction in the treatment of consumptive thirst complicated with urine microprotein |
| WU Suqin SHI Nan LI Ting |
| Department of Endocrinology, Heze Traditional Chinese Medicine Hospital, Shandong Province, Heze 274000, China |
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Abstract Objective To study clinical effect of Kuncao Qilian Decoction in the treatment of consumptive thirst complicated with urine microprotein. Methods Eighty-eight cases of consumptive thirst complicated with urine microprotein who were treated in Heze Traditional Chinese Medicine Hospital from June 2017 to December 2018 were selected. They were divided into control group 1 (28 cases), control group 2 (30 cases) and study group (30 cases) according to the random number table method. Control group 1 was treated with Enalapril Maleate Tablets, control group 2 was treated with Liuwei Dihuang Decoction on the basis of control group 1, and study group was treated with Kuncao Qilian Decoction on the basis of control group 1. Clinical efficacy and main symptoms score of traditional Chinese medicine, serum creatinine (Scr), cystatin C (CysC), endogenous creatinine clearance rate (Ccr), 24-hour urinary protein quantification, 24-hour urinary microprotein excretion and adverse reactions were compared among three groups. Results Total effective rate of study group was higher than that of control group 1 and control group 2, and that of control group 2 was higher than that of control group 1 (P < 0.05). After treatment, the scores of main symptoms score of traditional Chinese medicine in study group were lower than those in control group 1 and control group 2, while those in control group 2 were lower than those in control group 1 (P < 0.05). After treatment, Scr, CysC, 24-hour urinary protein quantification and 24-hour urinary microprotein excretion in study group were lower than those in control group 1 and control group 2, and those in control group 2 were lower than those in control group 1 (P < 0.05). Ccr of study group was higher than that of control group 1 and control group 2, and that of control group 2 was higher than that of control group 1 (P < 0.05). There was no significant difference in the incidence of adverse reactions among three groups (P > 0.05). Conclusion Kuncao Qilian Decoction is effective in treating consumptive thirst patients complicated with urinary microprotein. It has higher safety, which can provide reference for clinical treatment of the disease.
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