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| Clinical effect of Gangshu Lotion in rehabilitation of mixed hemorrhoid after operation |
| XIAO Shen QIN Jianping |
| Department of Traditional Chinese Medicine, Affiliated Hospital of Zunyi Medical College, Guizhou Province, Zunyi 563000, China |
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Abstract Objective To investigate the safety and efficacy of Gangshu Lotion in rehabilitation of mixed hemorrhoid after operation, to observe its influence on the change of prostaglandin E2 (PGE2) content in serum, in order to clarify its possible analgesic mechanism. Methods Sixty patients with mixed hemorrhoid admitted to Affiliated Hospital of Zunyi Medical College from January to July in 2017 were selected and divided into Chinese medicine group and western medicine group by random number table, with 30 cases in each group. Both groups were treated by Milligan-Morgan operation. After operation, the Chinese medicine group was treated by fumigation and sitz bath with self-made Gangshu Lotion. After operation, the western medicine group was treated by fumigation and sitz bath with povidone, both treatment until the wounds healed. All patients were assessed about wound pain, edema, hemafecia at 1 day, 3 days, 5 days after operation, and the levels of serum PGE2 were measured by enzyme-linked immunosorbent assay. Results The regression time of edema and wound healing of the Chinese medicine group were shorter than those of the western medicine group, with statistically significant difference (P < 0.05). 5 days after operation, the bleeding score of the Chinese medicine group was lower than that of the western medicine group, with statistically significant difference (P < 0.05). The scores of pain and the levels of PGE2 in the two groups at 3 days and 5 days after operation were significantly higher than those at 1 day after operation, and those of the Chinese medicine group were lower than those of the western medicine group, with statistically significant difference (P < 0.05). Conclusion Gangshu Lotion can effectively improve rehabilitation of mixed hemorrhoid after operation. The analgesic mechanism may be related to the decrease of the levels of serum PGE2.
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[1] 田振国，陈平.中国成人常见肛肠疾病流行病学调查[M]．武汉：武汉大学出版社，2015.
[2] 美国结直肠外科医师协会标准化工作委员会.痔诊断和治疗指南（2010修订版）[J].中华消化外科杂志，2012，11（3）：243-247.
[3] 中华中医药学会肛肠分会．肛裂、直肠脱垂、肛瘘、痔的诊断标准（试行草案）[J]．中医杂志，2003，44（s１）：313-314.
[4] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002.
[5] 周方敏，冯强，姚勇，等.改良外剥内扎术治疗环状混合痔的效果观察[J].医学理论与实践，2015，28（22）：3038-3039.
[6] 李悠然，谷云飞，陈邑岐，等.吻合器痔上黏膜钉合术的临床应用现状与反思[J].世界华人消化杂志，2015，23（14）：2245-2249.
[7] 高宗跃，周晓丽. PPH术并外痔切除术治疗Ⅲ、Ⅳ期重度环状混合痔的临床疗效观察[J].中国伤残医学，2013， 21（11）：123-125.
[8] 王冬青，刘丽萍，荀绍山.柏硝祛毒洗剂坐浴促进混合痔术后创面愈合的临床观察[J].河北中医，2014，36（12）：1799-1801.
[9] 李辉标，唐洪梅，丘振文，等.基于均匀设计-偏最小二乘回归优化四黄止痛喷雾剂中黄连与黄柏提取工艺的研究[J].今日药学，2016，26（2）：86-89.
[10] 郭洪利，刘向国.伏牛花的本草考证[J].中药材，2013，36（1）：148-151.
[11] 杨军，宋娜丽.威灵仙化学成分分离鉴定[J].中国实验方剂学杂志，2017，23（9）：41-45.
[12] 张敏.威灵仙化学成分及生物活性研究进展[J].中国生化药物杂志，2015，35（7）：165-168.
[13] 郑银驹，范回生，张杰.活血解毒饮对骨折术后患者血沉、C-反应蛋白、TNF-α及IL-1的影响[J].中医药导报，2015，21（12）：54-56.
[14] 陈莹璐，钟传篪，徐月，等.龙血竭胶囊合九华膏对环状混合痔术后创面促愈作用及对新生血管形成的影响[J].中国实验方剂学杂志，2017，23（8）：178-183.
[15] 孙凤伟.加味苦参汤坐浴熏洗对缓解肛瘘术后创面疼痛及促进愈合的效果观察[J].现代中西医结合杂志，2015， 24（36）：4076-4078.
[16] 章菊芬.中药熏洗对改善肛肠手术后疼痛及伤口愈合的疗效观察[J].辽宁中医杂志，2015，42（5）：994-996.
[17] 刘宗瑛.“天然植物抗菌液”镇痛作用及机理研究[D].成都：西南交通大学，2015.
[18] 郭朝卿，程英武.推拿局部镇痛机制的概述[J].湖北中医药大学学报，2015，17（1）：107-110.
[19] 刘春强，张岚.补中益气汤镇痛机制的初步探讨[J].中国肛肠病杂志，2015，35（2）：7-9.
[20] 王玉立，任天女，高玲，等.肛门病术后电针白环俞镇痛效果及其对血清前列腺E2的影响[J].长春中医药大学学报，2013，29（5）：806-807.
[21] 冀二锋.中药坐浴减轻混合痔术后疼痛的临床疗效观察[J].临床合理用药杂志，2016，9（17）：63-64.
[22] 白新发，徐玥声.中药坐浴在40例混合痔术后的应用[J].中国民族民间医药，2017，26（4）：95-96. |
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