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| Effect of Huayu Qutan Decoction in the treatment of intractable insomnia by professor Li Yan and its influence on serum cytokines |
| WANG Qi1 LI Yan2 LI Yong3 WU Xian4▲ |
1.Department of Cardiology, the First Affiliated Hospital of Heilongjiang Universtiy of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Traditional Chinese Medicine, the First Affiliated Hospital of Heilongjiang Universtiy of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
3.Department of Nephropathy, the Second Affiliated Hospital of Heilongjiang Universtiy of Chinese Medicine, Heilongjiang Province, Harbin 150001, China; 4.Department of Acupuncture, the First Affiliated Hospital of Heilongjiang Universtiy of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Objective To explore the clinical effect of Huayu Qutan Decoction in the treatment of intractable insomnia by professor Li Yan and its influence on serum cytokines. Methods From October 2018 to October 2019, 60 patients with intractable insomnia treated in Outpatient Department of LI Yan Famous Doctor Studio were selected and randomly divided into control group and treatment group, with 30 cases in each group. The control group was treated with Estazolam Tablets, while the treatment group was treated with Huayu Qutan Decoction on the basis of the control group. The two groups were treated for 3 courses (10 days as one course). The scores of TCM syndromes and Pittsburgh sleep quality index (PSQI) before and after treatment were compared between the two groups. The clinical efficacy and changes of serum cytokine levels in the two groups were observed before and after treatment. The occurrence of adverse reactions was recorded. Results The total scores of TCM syndromes and PSQI in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05), and the total scores of TCM syndromes and PSQI in the treatment group were significantly lower than those in the control group after treatment (P ＜ 0.05). The clinical efficacy of treatment group was better than that of control group, the dfference was statistically significant (P ＜ 0.05). After treatment, the serum levels of interleukin (IL)-1β, tumor necrosis factor α (TNF-α) and IL-6 in the two groups were significantly lower than those before treatment (P ＜ 0.05), and the serum levels of IL-1β, TNF-α and IL-6 in the treatment group were significantly lower than those in the control group after treatment (P ＜ 0.05). There was no significant difference in the incidence of total adverse reactions between the two groups (P ＞ 0.05). Conclusion Huayu Qutan Decoction can significantly improve the clinical symptoms and sleep quality of patients, enhance the therapeutic effect, reduce the levels of serum IL-1β, TNF-α and IL-6, and it is safe and has the value of promotion and application.
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