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| Clinical effect of phloroglucinol combined with Mifepristone and Rivanol in course of terminating mid-trimester pregnancy on scar uterus |
| REN Hongwei1 WANG Yan1 ZHANG Yuxiang1 ZHAO Yuan2 DOU Weina2 LIU Chunli1 ZHANG Limin1 HAN Wenfeng3 |
1.Department of Gynecology, the Seventh People′s Hospital of Hebei Province, Hebei Province, Dingzhou 073000, China;
2.Department of Obstetrics, the Seventh People′s Hospital of Hebei Province, Hebei Province, Dingzhou 073000, China;
3.Department of Oncology, the Seventh People′s Hospital of Hebei Province, Hebei Province, Dingzhou 073000, China |
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Abstract Objective To observe clinic effect of using Phloroglucinol combined with Mifepristone and Ethacridine Lactate Injection (Rivanol) in course of terminating mid-trimester pregnancy on scar uterus. Methods A total of 68 women with scar uterus (16-27 weeks gestation) desiring to terminate mid-trimester pregnancy were selected, and then they were divided into observation group and control group by random number method. In the observation group, 34 women were given Mifepristone and were injected abdominal intra-amniotically with Rivanol, as well given 80 mg of Phloroglucinol Injection intravenously when the cervix dilated 1 cm. In the control group, 34 women only were induced by Mifepristone combined with Rivanol. The time duration, cervical dilatation, suffering of the patients, laceration of cervix, the cervix edema, success rate of terminating pregnancy and adverse reactions of the two groups were observed, and postpartum hemorrhage were taken record. Results Time duration of terminating pregnancy in the observation group was shorter than that in the control group, the difference was statistically significant (P < 0.05). The pain degree in the observation group was significantly lower than that in the control group, the difference was statistically significant (P < 0.05). There were statistically significant differences in the proportion of patients with successful labor induction, cervical dilatation over 3 cm in 2 h, cervix edema, laceration of cervix between the two groups (P < 0.05). There was no statistically significant difference in postpartum hemorrhage and the incidence of adverse reactions (P > 0.05）. Conclusion Phloroglucinol combined with Mifepristone and Rivanol in terminating mid-trimester pregnancy on scar uterus have a good clinical effect. There is no obvious adverse reactions. It is safe and reliable, as well as simple and easy to operate. So it is worth to be widely promoted.
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[1] 欧阳新华.米非司酮配合利凡诺尔用于中期妊娠引产的疗效观察[J].临床合理用药杂志，2017，10（31）：89-91.
[2] 陈新宵，徐峰，吴洁丽，等.利凡诺尔配伍米非司酮、米索前列醇用于中期妊娠引产的有效性与安全性研究[J].中国地方病防治杂志，2014，29（S2）：240.
[3] 俞加正，祁锋，李响芝.探讨瘢痕子宫孕中期引产的安全方法[J].中国性科学，2018，27（1）：112-114.
[4] 张鹏雁.利凡诺联合米非司酮用于瘢痕子宫孕中期引产中的临床效果分析[J].北方药学，2019，16（6）：124+123.
[5] 刘俊杰，赵俊.现代麻醉学[M].2版.北京：人民出版社，1998.1431.
[6] 于芬兰.利凡诺联合米非司酮用于中期妊娠引产临床效果观察[J].医药前沿，2016，6（36）：56-57.
[7] 周诗云.利凡诺联合米非司酮用于中期妊娠引产的临床观察[J].医学理论与实践，2012，25（9）：1089-1090.
[8] 刘源.米非司酮用于剖宫产后瘢痕子宫引产的临床效果分析[J].药品评价，2018，15（9）：61-64.
[9] 张惜阴.实用妇产科学[M].2版.北京：人民卫生出版社，2003.
[10] 汪颖，杨秀珍.米非司酮联合利凡诺尔用于中期引产的临床效果[J].甘肃科技，2018，34（11）：114-115.
[11] 张恒云.米非司酮、米索前列醇配伍利凡诺终止中期妊娠89例临床观察[J].北方药学，2017，14（8）：22-23.
[12] 张莉.用利凡诺联合米非司酮对瘢痕子宫中期妊娠孕妇进行引产的效果评价[J].当代医药论丛，2018，16（16）：97-98.
[13] 丘苑清，赖映华，傅利琴.利凡诺联合米非司酮应用于初产妇中孕引产的临床疗效分析[J].中外医学研究，2018， 16（20）：134-135.
[14] 彭茂兰，涂建军.米非司酮联合米索前列醇片应用于50例瘢痕子宫中期妊娠引产的效果[J].当代医学，2019， 25（13）：138-139.
[15] 蔡素霞.米非司酮联合乳酸依沙吖啶注射液羊膜腔注射在瘢痕子宫再妊娠孕妇中晚期引产中的应用[J].河南医学研究，2019，28（5）：886-888.
[16] 李贤慧.对比分析口服米非司酮药物与羊膜腔内注射利凡诺药物用于中期引产效果[J].黑龙江医药，2017， 30（4）：826-828.
[17] 官兰芳，吴丽雅，陈燕娜，等.间苯三酚注射液用于绝经妇女取环的效果分析[J].现代诊断与治疗，2019（16）：2764-2766.
[18] 魏本雪，孙玉霞，王璐璐.间苯三酚联合缩宫素静滴促宫颈成熟及对产程进展的临床影响疗效观察[J].临床和实验医学杂志，2017，16（23）：2367-2369.
[19] 潘木香，李坤仪，吕淑莲，等.间苯三酚注射液用于绝经妇女取环的效果观察[J].右江医学，2018，46（4）：400-403.
[20] 齐育英，周玲，崔晓娟，等.利凡诺中期妊娠引产配合应用间苯三酚的疗效观察[J].临床合理用药杂志，2018， 11（14）：70-71.
[21] 冷颖，谭瑛.间苯三酚在绝经后取环术中应用的临床观察[J].临床合理用药杂志，2015，8（34）：89-90.
[22] 侯亚梅.依沙吖啶羊膜腔外注射联合间苯三酚在妊娠中期引产中的效果观察[J].河北医科大学学报，2016，37（1）：86-88. |
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