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A Meta-analysis of the effectiveness and safety of hyperthermia combined with intravenous chemotherapy for ovarian cancer |
CHEN Dazhan1 XU Ximing1 ZHOU Cheng2 CUI Haizhong2 |
1.The Third Department of Oncology, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.Department of Oncology, the First People's Hospital of Zaoyang, Hubei Province, Zaoyang 441200, China |
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Abstract Objective To evaluate the effectiveness and safety of hyperthermia combined with intravenous chemotherapy for ovarian cancer. Methods The databases of PubMed, Cochrane library, EMbase, China national knowledge internet, the Chinese biomedical literature database were searched from building to June 22, 2017. Randomized controlled studies on the efficacy and safety of hyperthermia combined with intravenous chemotherapy in the treatment of ovarian cancer were included, the quality of the included studies was evaluated using the quality evaluation criteria of the Cochrane Handbook version 5.1.0, and the Review Manager 5.1.0 software was used for data analysis. Results Twenty studies including 1275 cases of ovarian cancer were included. The results of the Meta-analysis exhibited that compared with intravenous chemotherapy alone, hyperthermia combined with intravenous chemotherapy could increase effective rate [RR = 1.58, 95%CI: 1.42-1.77, P < 0.00 001], effective rate of ascites[RR = 1.63, 95%CI: 1.32-2.02, P < 0.00 001], effective rate of CA125 [RR = 1.33, 95%CI: 1.14-1.55, P = 0.0003], the improvement rate of life quality [RR = 1.60, 95%CI: 1.24-2.06, P = 0.0003].Meanwhile, hyperthermia combined with intravenous chemotherapy did not significantly increase the incidence of myelosuppression, nausea and vomiting and liver and kidney dysfunction (P > 0.05). Conclusion Hyperthermia combined with intravenous chemotherapy may be more effective for ovarian cancer, improve life quality whereas adverse reactions are similar.
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