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| Clinical effect of Shihu Yangwei Decoction combined with Western medicine in the treatment of chronic atrophic gastritis |
| WANG Wenli1 WAN Qing2 DAI Hui1 |
1.Department of Pharmacy, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Jiangxi Province, Nanchang 330000, China;
2.Department of Internal Chinese Medicine, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Jiangxi Province, Nanchang 330000, China |
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Abstract Objective To explore clinical effect of Shihu Yangwei Decoction combined with Western medicine in the treatment of chronic atrophic gastritis (CAG). Methods One hundred patients with CAG who were admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from January 2018 to January 2019 were selected. The patients were randomly divided into control group (50 cases, Teprenone + Colloidal Bismuth Pectin therapy) and study group (50 cases, Shihu Yangwei Decoction + Teprenone + Colloidal Bismuth Pectin therapy) according to stratified randomization method. The clinical efficacy, traditional Chinese medicine symptom score, the levels of inflammatory factor [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)], oxidative stress index [nitric oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA) and serum gastrin-17 (G-17), pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PGⅡ) indicators and adverse reactions between two groups were compared. Results The total effective rate in study group was higher than that in control group (P < 0.05). After treatment, the scores of stomach tingling, food shortage, wasting, fatigue and fullness of stomach in two groups were lower than those before treatment, and the scores in study group were lower than those in control group (P < 0.01). After treatment, CRP, TNF-α and IL-6 in two groups were lower than those before treatment, and that in study group was lower than that in control group (P < 0.01). After treatment, the levels of G-17, PGⅠ and PGⅡ in two groups were higher than those before treatment, and the level in study group was higher than that in control group (P < 0.01). The levels of NO and SOD in two groups were higher than those before treatment, and the level in study group was higher than that in control group (P < 0.01). MDA level of two groups after treatment was lower than that before treatment, and that of study group was lower than that of control group (P < 0.01). There was no significant difference in incidence of adverse reactions between two groups (P > 0.05). Conclusion Shihu Yangwei Decoction combined with Western medicine has definite curative effect on CAG. It can significantly improve the clinical symptoms, it has high safety. It can provide reference for clinical treatment of CAG.
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