从“中气下陷”探讨直肠脱垂的病机

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Abstract In order to deepen the understanding of the pathogenesis of rectal prolapse in “middle qi collapse”, this paper expounds the two aspects of traditional Chinese medicine and modern medicine, in order to better guide the clinical practice, and also to point out the direction for the modeling of rectal prolapse in scientific research. In traditional Chinese medicine, “middle qi collapse” usually refers to a kind of disease, which is caused by qi deficiency, such as tissue relaxation and organ prolapse, indicating that “middle qi collapse” is directly related to the incidence of rectal prolapse. In modern medicine, the pathogenesis of rectal prolapse is the relaxation of rectal mucosa or the relaxation and separation of the rectum and its surrounding supporting tissue, and the rectum loses its support and slides down, which is basically consistent with the cognition of traditional Chinese medicine; as well as the experimental research on the establishment of artificial rectal prolapse model, the modeling method of chronic diarrhea coincides with the cognition of traditional Chinese medicine; in addition, rectal prolapse is common in fibulin-5 the weak mice, such as gene deficient mice, transgenic mice with low immune function or colitis mice, are also in line with the description of “qi deficiency can not be fixed, but it also falls off”, which indirectly indicates that the pathogenesis of rectal prolapse is related to the theory of “middle qi collapse”.

Key words： Middle qi collapse Rectal prolapse Pathogenesis Model of rectal prolapse

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	ZHOU Jiaojiao1 CHEN Qin1 LI Yufei1 WANG Xiaofeng1 CUI Guoce2▲ LI Huashan1▲

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ZHOU Jiaojiao1 CHEN Qin1 LI Yufei1 WANG Xiaofeng1 CUI Guoce2▲ LI Huashan1▲. Discussion on the pathogenesis of rectal prolapse from “middle qi collapse”[J]. 中国医药导报, 2020, 17(2): 120-123.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I2/120

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