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| Clinical value of thrombelastogram for the evaluation of coagulation function and prediction of metastasis in patients with moderate and advanced breast cancer |
| WANG Yan WU Jie SUN Tao▲ |
| Inpatient Ward of Galactophore, Cancer Hospital of China Medical University Liaoning Cancer Hospital, Liaoning Province, Shenyang 110042, China |
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Abstract Objective To study and investigate the clinical value of thrombelastogram for the evaluation of coagulation function and prediction of metastasis in patients with moderate and advanced breast cancer. Methods One hundred and fourteen patients with moderate and advanced breast cancer admitted to Liaoning Cancer Hospital ("our hospital" for short) from January 2016 to January 2017 were selected and divided into two groups, with 56 cases in group Ⅰ (Ⅰ+Ⅱ stage of patients with breast cancer) and 58 cases in group Ⅱ (Ⅲ+Ⅳ stage of patients with breast cancer), of which, there were 18 cases with metastasis (metastasis group) and 40 cases without metastasis (no metastasis group) in group Ⅱ. Another 50 healthy controls in our hospital at the same time were selected as normal control group. The thrombelastogram was used to detect response time (R value), coagulation time (K value), maximum amplitude (MA value), angle. The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and thrombin time (TT) were tested by routine examination. Results The R value, K value, MA value, angle in group Ⅰ, Ⅱ were all higher than those of normal control group, and R value, K value, MA value, angle in group Ⅱ were all higher than those of group Ⅰ, the differences were all statistically significant (all P ＜ 0.05). The PT, APTT, TT, FIB in group Ⅰ, Ⅱ were all higher than those of normal control group, but the differences were not statistically significant (P ＞ 0.05), there were also no statistically significant differences of PT, APTT, TT, FIB between group Ⅰ and group Ⅱ (P ＞ 0.05). The R value, K value, MA value, angle in metastasis group were all higher than those of no metastasis group, the differences were all statistically significant (P ＜ 0.05), while there were no statistically significant differences of PT, APTT, TT, FIB between metastasis group and no metastasis group (P ＞ 0.05). Conclusion Compared with routine coagulation function examination, thrombelastogram can evaluate the coagulation function of breast cancer more effectively, which has an important value for prediction of breast cancer metastasis.
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