冠心病患者血清Angptl2、Angptl4水平与冠状动脉狭窄程度的关系

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Abstract Objective To explore the relationship between the levels of serum angiopoietin-like protein 2 (Angptl 2) and angiopoietin-like protein 4 (Angptl 4) and the severity of coronary artery stenosis in patients with coronary heart disease. Methods From June 2016 to December 2018, 98 csaes with coronary heart disease examined by coronary angiography in Liaoning Health Industry Group General Hospital of Fushun Mining Bureau were selected as coronary heart disease group. According to Gensini scores, they were divided into low-risk subgroup (36 cases), medium-risk subgroup (32 cases) and high-risk subgroup (30 cases). At the same time, 62 healthy persons with normal results of coronary angiography were enrolled as control group. The levels of serum of blood glucose, blood lipids, blood pressure, Angptl 2 and Angptl 4 between two groups were compared. Pearson correlative analysis was used to analyze the correlation between the levels of serum Angptl 2, Angptl 4 and Gensini scores in patients with coronary heart disease. Results The serum Angptl 2 levels in coronary heart disease group were higher than those in control group, while the serum Angptl 4 levels were lower than those in control group, and the differences were highly statistically significant (all P < 0.01). There were no significant differences in blood lipids, blood glucose and blood pressure between two groups (P > 0.05). Angptl 2, TG and LDL-C levels in high-risk subgroup were higher than those in medium-risk subgroup and low-risk subgroup, and medium-risk subgroup were higher than low-risk subgroup, the levels of Angptl 4 in high-risk subgroup were lower than those in medium-risk subgroup and low-risk subgroup, and medium-risk subgroup was lower than low-risk subgroup, and the differences were statistically significant (all P < 0.05). Pearson correlative analysis showed that Angptl 2 levels were positively correlated with Gensini scores (r = 0.504, P ＜ 0.01), and Angptl 4 levels were negatively correlated with Gensini scores (r = -0.598, P ＜ 0.01). Conclusion Angptl 2 and Angptl 4 are expected to provide new ideas for the diagnosis of coronary heart disease.

Key words： Coronary heart disease Angiopoietin-like protein 2 Angiopoietin-like protein 4 Severity of coronary artery stenosis

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	LI Zhongqiang LIN Jihong YI Renke

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LI Zhongqiang LIN Jihong YI Renke. Relationship between the levels of serum Angptl 2 and Angptl 4 and severity of coronary artery stenosis in patients with coronary heart disease[J]. 中国医药导报, 2020, 17(2): 109-112.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I2/109

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