化痰通遂汤治疗痰浊壅塞、瘀阻经络型脑卒中偏瘫患者的效果

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Abstract Objective To analyze the clinical effect and the possible mechanism of Huatan Tongsui Decoction in the treatment of the stroke patients with hemiplegia. Methods A total of 120 stroke hemiplegia patients in Yiling Hospital of Hebei Province from January 2015 to December 2016. According to the random number table method they were divided into control group and treatment group, with 60 cases in each group. The treatment group was given basic treatment plus rehabilitation training and oral Huatan Tongsui Decoction, one dose a day, taken twice in the morning and evening for 45 days. The control group was given the same treatment as the treatment group except for Huatan Tongsui Decoction. The clinical symptoms were scored before and after treatment, and the upper limb motor function was evaluated by Fugl-Meyer scale. The electromyography score (iEMG) of deltoid muscle, triceps brachii muscle and extensor muscle group of forearm were detected by the surface electromyography. The serum total cholesterol (TC), triglyceride (TG), and hemorheology indexes (including whole blood viscosity, fibrinogen and plasma viscosity) were measured before and after treatment in two groups. Results Compared with before treatment, the clinical symptom scores of two groups were decreased after treatment (P ＜ 0.05). There were no significant differences in clinical symptom scores between two groups (P ＞ 0.05). The scores of upper limb motor function and iEMG in two groups were both increased, and those in treatment group were higher than those in control group (P ＜ 0.05). The levels of TC and TG in two groups were decreased and those in treatment group were lower than those in control group (P ＜ 0.05). There were no significant differences in hemorheology indexes in the control group after treatment (P ＞ 0.05). Total blood viscosity, plasma viscosity and fibrinogen content were decreased in treatment group (P ＜ 0.05), and those in treatment group were lower than those in control group (P ＜ 0.05). Conclusion The mechanism of Huatan Tongsui Decoction treating stroke may be related to reducing serum triglyceride, improving blood rheology, so as to improve the clinical symptoms of the patients.

Key words： HuatanTongsui Decoction Rehabilitation training Phlegm congestion and stasis obstructing meridian type stroke Hemiplegia

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	WANG Jing LIU Chunru SUN Yonghui WANG Miaomiao JI Yueran

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WANG Jing LIU Chunru SUN Yonghui WANG Miaomiao JI Yueran. Effect of Huatan Tongsui Decoction for patients with stroke hemiplegia due to phlegm congestion and stasis obstructing meridian[J]. 中国医药导报, 2020, 17(2): 105-108.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I2/105

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