|
|
|
| Clinical application value of ACTH, CORT, IL-18 and TNF-α in predicting depression |
| TIAN Haihua1 CHEN Shoulin1 XU Guoan2 LI Guangxue2 WAN Xiaohan2 GAO Shugui2 |
1.Department of Clinic Laboratory, Ningbo Kangning Hospital, Zhejiang Province, Ningbo 315201, China;
2.Affective Disorder Ward, Ningbo Kangning Hospital, Zhejiang Province, Ningbo 315201, China |
|
|
|
Abstract Objective To investigate clinical application value of ACTH, CORT, IL-18 and TNF-α in predicting depression. Methods A total of 60 patients with first-diagnosis depression admitted to Ningbo Kangning Hospital (“our hospital” for short) from June 2017 to June 2019 were selected as depression group, a total of 60 healthy persons who underwent routine physical examination in our hospital during the same period were selected as the control group. Serum levels of ACTH, CORT, IL-18 and TNF-α in two groups were detected respectively to analyze the correlation with depression. Results The serum levels of ACTH, CORT, IL-18 and TNF-α in depression group were significantly higher than those in the control group (P < 0.05). The serum levels of ACTH was positively correlated with total score of Hamilton depression scale (HAMD) and HAMD factors (P < 0.05), such as depression, guilt, insomnia at the end of early sleep, mental anxiety, somatic anxiety, diurnal and nighttime changes, and impaired ability. CORT was positively correlated with total score of HAMD and factors (P < 0.05), such as depression, insomnia at the end of early sleep, work interest, somatic anxiety, weight loss, diurnal and nighttime changes, and paranoid symptoms. The total score of HAMD was positively correlated with IL-18 (P < 0.05). IL-18 was positively correlated with HAMD factors such as depression, early insomnia with difficulty in falling asleep, somatic anxiety, general symptoms, paranoid symptoms, obsessive-compulsive symptoms, and impaired ability (P < 0.05). TNF-α was also positively correlated with total score of HAMD and its factors such as depression, insomnia at the end of early sleep, work interest, mental anxiety, somatic anxiety, general symptoms and impaired ability (P < 0.05). Conclusion The serum levels of ACTH, CORT, IL-18 and TNF-α in patients with depression are higher. Direct detection of the above indicators has certain clinical application value in predicting the occurrence of depression.
|
|
|
|
|
|
[1] 汪宏，于恩彦.老年抑郁症疲乏感的研究进展[J].浙江临床医学，2017，19（5）：983-985.
[2] 李卓，张海三，李杰，等.老年抑郁症患者下丘脑-垂体-肾上腺轴功能和垂体、肾上腺体积的变化[J].实用医学杂志，2016，32（14）：2329-2332.
[3] 金齐颖，吴红芳，马原源，等.抑郁症中细胞因子作用机制及其治疗进展[J].现代医药卫生，2018，34（1）：44-46.
[4] 徐宇浩，于明，李月峰，等.血清学指标回归模型在老年性抑郁症和抑郁状态鉴别诊断中的应用价值[J].中华老年医学杂志，2018，37（9）：984-987.
[5] 吕薇，白洁.抑郁症中免疫系统与五羟色胺系统的相互作用[J].中国老年学杂志，2016，36（7）：1757-1759.
[6] 申永辉，陈致宇，张学平，等.血清炎症细胞因子水平与抗抑郁疗效的关系[J].浙江医学，2019，41（13）：1370-1373.
[7] Haroon E，Daguanno AW，Woolwine BJ，et al. Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder [J]. Psychoneuroendocrinology，2018，95：43-49.
[8] 崔利军，崔伟，马小红，等.头发、血浆皮质醇水平变化与抑郁症的相关性研究[J].中国神经精神疾病杂志，2017， 43（1）：43-47.
[9] 崔旅纯，吴志国，方怡儒.抑郁症症状维度与诊治效应研究进展[J].中华精神科杂志，2018，51（4）：269-272.
[10] 王玉成.艾司西酞普兰联合喹硫平对抑郁症患者下丘脑-垂体-肾上腺素轴的影响[J].中国乡村医药，2015， 9：26-27.
[11] 张贵锋，吴晓玲，曾统军，等.通元针法联合隔药盐灸神阙对产后抑郁大鼠行为和下丘脑-垂体-肾上腺轴的影响[J].实用医学杂志，2018，34（8）：1262-1266.
[12] 许墨菊.血清甲状腺激素和肾上腺皮质激素水平与老年抑郁症的发生相关性研究[J].河北医学，2019，25（6）：1010-1013.
[13] 朱海兵，王丹峰，高云，等.未用药抑郁症自杀者的临床特征与HPA轴功能分析[J].中国神经精神疾病杂志，2016，42（10）：596-600.
[14] Zeni ALB，Camargo A，Dalmagro AP. Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice [J]. Steroids，2017，125：131-136.
[15] 伏箫燕，李海燕，崔婷，等.IL-1β、IL-6及下游IDO激活与大鼠抑郁行为的关系研究[J].重庆医学，2018，47（15）：1986-1989.
[16] 王贵锋，庞妩燕，王丽，等.氟西汀对糖尿病合并抑郁症患者血浆TNF-α、IL-6及BDNF水平的影响[J].国际精神病学杂志，2017，44（5）：826-828.
[17] 陆梅娟，莫亚莉.抑郁症患者血清TNF-α、IL-8、ICAM-1、NF-κB水平及其意义[J].中国现代医学杂志，2018， 28（32）：117-120.
[18] Santos M，Carvalho S，Lima L，et al. The role of IL18-607C>A and IL18-137G>C promoter polymorphisms in antidepressant treatment phenotypes：A preliminary report [J]. Neurosci Lett，2016，622：107-112.
[19] Huang MH，Chen MH，Tu PC，et al. Elevated tumor necrosis factor-alpha receptor subtype 1 and the association with abnormal brain function in treatment-resistant depression [J]. J Affect Disord，2018，235：250-256.
[20] Wang P，Feng YB，Wang L，et al. Interleukin-6： Its role and mechanisms in rescuing depression-like behaviors in rat models of depression [J]. Brain Behave Immun，2019， 35：1250-1256.
[21] 毕斌，何军，罗洁，等.血清IL-6、IL-18及TNF-α水平对抑郁症首次发作的诊断价值[J].贵阳医学院学报，2016，41（5）：546-550.
[22] Kim YK，Na KS，Myint AM，et al. The role of pro-inflammatory cytokines in neuroinflammation，neurogenesis and the neuroendocrine system in major depression [J]. Prog Neuropsychopharmacol Boil Psychiatry，2016，64：277-284. |
|
|
|
