HIV并肺结核患者与单纯肺结核患者临床特征的比较分析

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Abstract Objective To analyze the clinical characteristics of human immunodeficiency virus (HIV) patients with pulmonary tuberculosis and simple pulmonary tuberculosis, and to further evaluate the accuracy of G-xpert test, PPD test, Mycobacterium tuberculosis(MTB) routine sputum examination, sputum culture and T cell spot test in diagnosis of two groups of patients. Methods The clinical characteristics, clinical manifestations and diagnostic methods of 49 patients with HIV and tuberculosis and 57 patients with simple tuberculosis admitted to the Third People′s Hospital of Kunming from January 2017 to December 2018 were analyzed. Results The positive rates of sputum examination, PPD test and G-xpert test were 12%, 23% and 54% in 49 HIV patients with pulmonary tuberculosis, respectively. The positive rates of sputum examination, PPD test and Xpert/MTB RIF test in 57 patients with pulmonary tuberculosis were 25%, 51% and 48% respectively. The diagnostic accuracy of G-xpert test was higher in HIV patients with pulmonary tuberculosis（P ＜ 0.05）. Conclusion Different diagnostic methods, such as G-xpert test, PPD test, conventional sputum MTB test, sputum culture, T-cell spot test, have different diagnostic accuracy in patients with HIV and tuberculosis and patients with simple tuberculosis. Xpert/MTB RIF examination has more advantages in the diagnosis of HIV patients with tuberculosis.

Key words： Tuberculosis with HIV Tuberculosis Xpert/MTB RIF PPD

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	LU Nihong LIU Honglu LYU Zhengxuan CHEN Yangjun LIU Jun JIANG Jianjie▲

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LU Nihong LIU Honglu LYU Zhengxuan CHEN Yangjun LIU Jun JIANG Jianjie▲. Comparative analysis of clinical characteristics between pulmonary tuberculosis patients with HIV and simple pulmonary tuberculosis[J]. 中国医药导报, 2020, 17(2): 97-100.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I2/97

[1] World Health Organization WHO Treatment Guidelines for Drug. Resistant Tuberculosis-2016 update [M]. Geneva：World Health Organization.2016.
[2] Ding P，Li X，Jia Z，et al. Multidrug-resistant tuberculosis （MDR-TB） disease burden in China：a systematic review and spatio-temporal analysis [J]. BMC Infect Dis，2017， 17（1）：57.
[3] Ka D，Ngom Gueye NF，Fall N，et al. Prevalence of TB/HIV coinfection in antiretroviral-naive patients at the Fann Ambulatory Treatment Center in Dakar [J]. Med Sante Trop，2017，27（4）：392-396.
[4] 人民共和国国家卫生和计划生育委员会.肺结核诊断WS288-2017[J].中国感染控制杂志，2018，17（7）：642-652.
[5] World Health Organization Global tuberculosis report 2018 [M]. Geneva：World Health Organization，2018.
[6] Pinto CMA，Carvalho ARM. The HIV/TB coinfection severity in the presence of TB multi-drug resistant strains [J]. Ecological Complexity，2017，32：1-20.
[7] 贾春辉，王磊，荆凡辉，等.艾滋病合并巨细胞病毒感染48例临床分析及T淋巴细胞亚群特点[J].中华内科杂志，2019，58（3）：191-197.
[8] 庞增，何日东，陈勇军，等.HIV/AIDS合并肺部感染40例临床分析[J].广东医科大学学报，2018，36（1）：97-99.
[9] 马卫国，韦永孜，邓世富，等.HIV合并肺结核与单纯肺结核的临床特征分析及抗结核治疗效果对比[J].现代生物医学进展，2017，17（18）：3570-3573.
[10] 张孟璋，李庶甘，李茵，等.单纯肺结核病与HIV/AIDS合并肺结核的临床特征观察[J].中国现代医生，2017， 55（26）：86-88.
[11] 范桂权，胥富波，漆俊，等.HIV感染合并结核病的临床特征及相关影响因素分析[J].传染病信息，2018，31（6）：548-551.
[12] 郭安良，焦艳梅，徐哲，等.艾滋病免疫重建炎性综合征研究进展[J].中华实验和临床病毒学杂志，2019，33（1）：99-102.
[13] 彭程，王立非，梁芳芳，等.比较HIV阳性和HIV阴性患者粟粒型结核CT征象[J].罕少疾病杂志，2018，25（4）：14-16.
[14] 袁婧，刘俊，金永梅，等.合并艾滋病的结核病患者血液结核分枝杆菌培养阳性率影响因素的分析[J].临床肺科杂志，2018，23（7）：1175-1178.
[15] 商勇，陆燕春，解承鑫，等.不同肺结核类型患者细胞免疫功能相关性研究[J].临床肺科杂志，2017，22（7）：1176-1179.
[16] 张炜平，秦超.支气管肺泡灌洗液Xpert MTB/RIF检验在痰涂阴肺结核发现中的价值[J].中国生化药物杂志，2017，37（2）：302-304.
[17] 钟剑峰，童涌，童照威，等.肺泡灌洗液Xpert MTB/RIF检测在涂阴肺结核早期诊断中的应用价值[J].浙江医学，2018，40（8）：836-838.
[18] Chen Y，Jiang J，Jiang H，et al. Mycobacterium gordonae in Patient with Facial Ulcers，Nosebleeds，and Positive T-SPOT.TB Test，China [J]. Emerg Infect Dis，2017，23（7）：1204-1206.
[19] 范伟光.探讨结核感染T细胞斑点试验在辅助诊断 AIDS合并结核病中的应用价值[J].中国预防医学杂志，2017，18（1）：79-81.
[20] Dorman SE，Schumacher SG，Alland D，et al. Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and Rifampicin resistance：a prospective multicentre diagnostic accuracy study [J]. Lancet Infect Dis，2018，18（1）：76-84.
[21] Walzl G，Mcnerney R，Du Plessis N，et al. Tuberculosis：advances and challenges in development of new diagnostics and biomarkers [J]. Lancet Infect Dis，2018，18（7）：e199-e210.