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| The relationship between serum thrombospondin-1 level and severity of systemic lupus erythematosus |
| WU Wei HE Dongchu |
| Department of Integrated TCM and Western Medicine, Central War Zone General Hospital of Chinese People′s Liberation Army, Hubei Province, Wuhan 430070, China |
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Abstract Objective To investigate the relationship between the level of serum thrombospondin-1 (TSP-1) and the disease severity of patients with systemic lupus erythematosus (SLE). Methods One hundred and ten SLE patients admitted to Central War Zone General Hospital of Chinese People′s Liberation Army (“our hospital” for short) from January 2010 to December 2018 were selected as observation group. According to the SLE disease activity index (SLEDAI-2000) score, the patients were divided into remission period (49 cases, SLEDAI-2000 score < 5 points) and active period (61 cases, SLEDAI-2000 score ≥ 5 points). Another 50 volunteers who underwent physical examination in our hospital during the same period were selected as control group. The levels of serum TSP-1 in control group and observation group, remission period and active period were compared with other clinical indicators. The relationship between serum TSP-1 level and SLE complications was analyzed. Pearson correlation analysis was used to analyze the correlation between serum TSP-1 level and other clinical indicators. Results The level of serum TSP-1 in observation group was higher than that in control group, while the levels of hemoglobin, platelet, C3 and C4 in observation group were lower than those in control group (P < 0.05). The level of TSP-1 in active phase was higher than that in remission phase, while levels of hemoglobin, platelet, C3 and C4 in active phase were lower than those in remission phase (P < 0.05). The serum TSP-1 level of SLE patients with oral ulcer, rash, alopecia, arthritis, lupus nephritis and hemolytic anemia was higher than that of those without symptoms (P < 0.05). Pearson correlation analysis showed that TSP-1 was negatively correlated with hemoglobin, platelet, C3 and C4 (r = -0.471, -0.462, -0.492, -0.537, P < 0.05), but not with creatinine, urea nitrogen and 24h urinary protein (P > 0.05). Conclusion There is an abnormal increase in serum TSP-1 level of SLE patients, and the degree of increase is closely related to the disease severity of patients. At the same time, the abnormal release of TSP-1 may have some effect on the complications of SLE.
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