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| The value of Caprini score combined with D-dimer in the diagnosis of deep venous thrombosis in gynecological malignant tumors |
| DAI Lingyu1 ZHAO Hongle2 ZHAO Guangfang1 LYU Meng2 SHI Yanmei2 ZHANG Shuxiang2 |
1.School of Nursing, Weifang Medical College, Shandong Province, Weifang 261053, China;
2.Department of Nursing, the First Affiliated Hospital of Shandong First Medical University, Shandong Province, Ji′nan 250013, China |
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Abstract Objective To investigate the value of Caprini score combined with D-dimer in the diagnosis of deep venous thrombosis (DVT) in patients with gynecologic malignancies. Methods A retrospective analysis of 95 patients with DVT after gynecologic malignancies and 95 patients with concurrent DVT who were admitted to the First Affiliated Hospital of Shandong First Medical University from January 2017 to January 2019. The general data of the two groups were retrospectively analyzed. The values of Caprini score, D-dimer value and the combined diagnosis of DVT in gynecologic malignant tumor were compared. Results The Caprini score and D-dimer in the DVT group were significantly higher than those in the control group (P < 0.01). The ROC curve of DVT in patients with gynecologic malignant tumors was diagnosed by Caprini score, D-dimer and the combination of the two. The lower areas were 0.817, 0.860 and 0.884, respectively. The sensitivity was 67.4%, 90.5% and 61.1%, respectively. The specificities were 87.4%, 69.5% and 95.8%, respectively. The false negative rates were 32.6%, 9.5% and 39.0%, respectively. The positive rates were 12.6%, 30.5% and 4.2%, respectively. The positive predictive values were 85.3%, 74.8% and 93.6%, respectively. The negative predictive values were 72.8%, 88.0% and 71.1%, respectively. The positive likelihood ratios were 5.35, 2.97 and 14.50, respectively. The negative likelihood ratios were 0.37, 2.97 and 0.42, respectively. The likelihood ratio of Caprini score combined with D-dimer in the diagnosis of gynecologic malignant tumor after DVT was compared with Caprini score alone the difference was statistically significant (P < 0.01), the difference was not statistically significant compared with D-dimerm alone (P > 0.05). Conclusion Caprini score combined with D-dimer is an economic and safe early screening method with certain clinical value.
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