依达拉奉联合丙戊酸钠治疗脑卒中后癫痫的效果

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Abstract Objective To investigate the efficacy of Edaravone combined with Sodium Valproate in the treatment of post-stroke epilepsy (PSE). Methods The clinical data of 102 patients with PSE who were treated in Tianjin Huanhu Hospital from January 2016 to March 2018 was analyzed retrospectively. According to the different treatment methods, the patients were divided into control group (55 cases) and study group (47 cases). The control group was treated with Sodium Valproate, and the study group was treated with Edaravone on the basis of the control group. The clinical efficacy, seizure frequency, duration, levels of neuron specific enolase (NSE), inflammatory factors and adverse reactions were compared between the two groups. Results The total effective rate of the study group was significantly higher than the control group (P ＜ 0.05). Compared with those before treatment, the number of epileptic seizures decreased and the duration of epileptic seizures shortened in the two groups after treatment. After treatment, the number of epileptic seizures in the study group was less than the control group, and the duration of epileptic seizures was shorter than the control group (P ＜ 0.05). Compared with those before treatment, the levels of serum interleukin-1β (IL-1β), interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α) in the two groups were decreased, after treatment, which in the study group were lower than the control group after treatment (P ＜ 0.05). There was no significant difference in serum NSE level between the two groups after 3, 6 months and 12 months of treatment (P ＞ 0.05). The serum NSE level in the study group was lower than the control group after 1 month of treatment (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Edaravone combined with Sodium Valproate in the treatment of PSE can rapidly improve clinical symptoms and reduce the level of NSE with definite curative effect. It can also reduce the level of inflammatory factors without increasing the incidence of adverse reactions.

Key words： Edaravone Sodium Valproate Stroke Epilepsy Efficacy

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	LI Xun1 LIAO Haibing1 LIU Shoufeng1 CAI Hao1 DOU Yuchao1 LI Changping2 WANG Shimin1

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LI Xun1 LIAO Haibing1 LIU Shoufeng1 CAI Hao1 DOU Yuchao1 LI Changping2 WANG Shimin1. Effectiveness of Edaravone combined with Sodium Valproate in the treatment of post-stroke epilepsy[J]. 中国医药导报, 2020, 17(2): 69-72.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I2/69

[1] Fu CY，Chen SJ，Cai NH，et al. Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism [J]. Neurol Res，2019，41（4）：378-383.
[2] 王湘庆.缺血性脑卒中后痫性发作临床和基础研究进展[J].中华老年心脑血管病杂志，2016，18（8）：785-787.
[3] 张华.拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志，2016，32（12）：1085-1087.
[4] 麦少珍，何敬成，杜斌，等.丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效及安全性[J].中国医院用药评价与分析，2016，16（7）：908-910.
[5] 祝叶，林珍，郑忠涛.培元通脑胶囊联合依达拉奉治疗急性脑梗死的临床研究[J].现代药物与临床，2019，34（8）：2322-2325.
[6] 邢岩.中国急性缺血性脑卒中诊治指南2010[J].中国临床医生，2011，2（3）：50-59.
[7] 王薇薇，王新德.第六届全国脑血管病学术会议纪要[J].中华神经科杂志，2004，37（4）：346-348.
[8] 林岚，王晓燕，杨淑，等.丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫的临床观察[J].中国药房，2016，27（33）：4634-4637.
[9] 许月光.脑卒中后癫痫临床特征的回顾性研究[D].吉林：吉林大学，2019.
[10] 黄丹，黄影柳，张和妹，等.左乙拉西坦联合高压氧对脑卒中后癫痫患者血清Hcy、NSE水平变化及生活质量的影响[J].广东医学，2018，39（16）：2523-2527.
[11] Fox CK，Jordan LC，Beslow LA，et al. Children with post-stroke epilepsy have poorer outcomes one year after stroke [J]. Int J Stroke，2018，13（8）：820-823.
[12] 符泽娟.脑卒中后癫痫发作的临床特点和视频脑电图分析[J].临床和实验医学杂志，2016，15（7）：714-716.
[13] 徐昆明，杨玉先，温茂昌，等.左乙拉西坦联合丙戊酸钠治疗脑卒中后癫痫的临床效果及安全性[J].癫痫与神经电生理学杂志，2018，27（1）：34-36.
[14] 王晓周，莫丽亚，李晓凤，等.依达拉奉治疗老年脑卒中后迟发性癫痫的疗效[J].中国老年学杂志，2013，33（2）：408-409.
[15] 齐智慧，李东晓.依达拉奉联合丙戊酸钠对脑卒中后继发癫痫患者的临床疗效、神经元特异性烯醇化酶、炎症因子及不良反应的研究[J].国际神经病学神经外科学杂志，2019，46（2）：150-153.
[16] Huang YH，Chi NF，Kuan YC，et al. Efficacy of phenytoin，valproic acid，carbamazepine and new antiepileptic drugs on control of late-onset post-stroke epilepsy in Taiwan [J]. Eur J Neurol，2015，22（11）：1459-1468.
[17] Kobayashi S，Fukuma S，Ikenoue T，et al. Effect of Edaravone on Neurological Symptoms in Real-World Patients With Acute Ischemic Stroke [J]. Stroke，2019，50（7）：1805-1811.
[18] 齐宝奎，臧兆萍，李志茹，等.内皮素-1在红藻氨酸致癫痫大鼠海马区的表达及依达拉奉的干预作用[J].中国老年学杂志，2017，37（9）：2105-2107.
[19] 蔡伦.癫痫相关性抑郁的炎症机制研究进展[J].重庆医学，2016，45（33）：4716-4718.
[20] 温玉梅，闫致旺.依达拉奉辅助治疗全身强直-阵挛发作癫痫的疗效与机制[J].河北医药，2010，32（17）：2368-2369.