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| Effect of Tian Meng Capsules combined with Sertraline Hydrochloride Tablets in the treatment of post-stroke depression |
| PANG Zhaofeng1 XU Wuhua1 WU Wanxia1 ZHU Donglin2 CHEN Haishan1 ZHOU Huiyi1 |
1.Rehabilitation Department, Guangzhou Red Cross Hospital (Guangzhou Red Cross Hospital Affiliated to Medical College of Ji'nan University), Guangdong Province, Guangzhou 510220, China;
2.Laboratory Department, the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province, Guangzhou 510000, China |
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Abstract Objective To explore the clinical efficacy of Tian Meng Capsules combined with Sertraline Hydrochloride Tablets in the treatment of post-stroke depression (PSD). Methods Ninety-five patients with PSD who were admitted to Guangzhou Red Cross Hospital from January to November 2018 were selected as subjects. The patients were divided into control group (47 cases) and study group (48 cases) by random number table method. The control group was given Sertraline Hydrochloride Tablets, the study group was given Tian Meng Capsules combined with Sertraline Hydrochloride Tablets. The clinical efficacy, serum 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), depression and anxiety, sleep quality and adverse reactions were compared between the two groups. Results The total clinical effective rate in the study group was higher than that in the control group (P ＜ 0.05). After treatment, the levels of 5-HT and BDNF in the study group were higher than those in the control group (P ＜ 0.05). The scores of Hamilton depression scale, Hamilton anxiety scale and Pittsburgh sleep quality index in the study group were lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Tian Meng Capsules combined with Sertraline Hydrochloride Tablets is effective in the treatment of PSD. It can improve depression and anxiety, and enhance sleep quality, the adverse reactions are low. It can be widely used in clinic.
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