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| Relationship between SFRP5 expression and insulin resistance in pregnant women with gestational diabetes mellitus |
| YANG Xiaoyan WANG Guixiang LI Tao |
| Department of Obstetrics, Maternal and Child Health Hospital of Inner Mongolia, Inner Mongolia Autonomous Region, Hohhot 010050, China |
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Abstract Objective To discuss the relationship between the expression of SFRP5 and insulin resistance of pregnant women with gestational diabetes mellitus (GDM). Methods Fifty cases of normal pregnant women in Maternal and Child Health Hospital of Inner Mongolia from January 2016 to March 2017 were selected as control group, and 50 cases with GDM were selected as experimental group. The level of fasting insulin, fasting blood glucose and blood lipid from 24 to 28 weeks of pregnancy was compared between the two groups. Enzyme-linked immunosorbent method was used to test the expression of SFRP5 in cubital vein serum of the puerperas in the two groups during cesarean section. Subcutaneous adipose of 30 cases between the two groups was taken respectively, and the expression of SFRP5 mRNA was tested by RT-PCR. Results SFRP5 was expressed in serum and adipose of the experimental group and the control group. The expression of SFRP5 in serum and adipose of the experimental group was lower than that in control group significantly （P < 0.01）. The serum SFRP5 was negatively correlated with HOMA-IR, cholesterol, triglyceride, LDL-C （r = -0.5706, -0.1479, -0.1541, -0.1366, all P < 0.05）, the serum SFRP5 and high density lipoprotein have the positive correlation relationship (r = 0.0866, P < 0.01）. Conclusion The abnormal expression of SFRP5 is related to the occurrence and development of GDM. Through clinical monitoring the expression of SFRP5, the occurrence of insulin resistance can be discovered early, and reduce the morbidity of GDM. During pregnancy, offer good nutrition guidance and strict weight-control to pregnant women can reduce the occurrence of insulin resistance, and improve the pregnancy success rate in GDM.
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