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| Changes and clinical significance of intercellular adhesion molecule-1 and eosinophils levels in patients with bronchial asthma |
| ZHANG Changsheng ZHANG Haitao |
| Department of Respiratory Medicine, Nanjing Brain Hospital the Affiliated Brain Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, China |
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Abstract Objective To investigate the changes and clinical significance of intercellular adhesion molecule-1 (ICAM-1) and eosinophils (EOS) in patients with bronchial asthma. Methods From January 2012 to December 2017, a total of 86 patients with bronchial asthma treated in Nanjing Brain Hospital (“our hospital” for short) were divided into acute attack group (45 cases) and remission group (41 cases) according to their condition and symptoms. A total of 52 people undergoing health examination in our hospital at the same time were selected as control group. The levels of serum ICAM-1, EOS and pulmonary function were compared among the three groups, and the correlation was analyzed. Results The level of ICAM-1 and EOS in acute attack group and remission group were significantly higher than those in control group, while acute attack group was significantly higher than remission group, and the differences were statistically significant (P ＜ 0.05). Maximal voluntary ventilation (MVV)/predicted value, peak expiratory flow (PEF), one second forced breath volume (FEV1) and forced vital capacity (FVC) in acute attack group and remission group were lower than those in control group, while those in acute attack group were lower than those in remission group, and the differences were statistically significant (P ＜ 0.05). Spearman correlation results showed that ICAM-1, EOS levels were negatively correlated with FVC, FEV1 in patients with bronchial asthma（r = -0.652, -0.548; r = -0.549, -0.598, P ＜ 0.05）. Conclusion ICAM-1 and EOS may be involved in the occurrence and development of bronchial asthma. The analysis of ICAM-1 content and EOS count have important clinical significance for the diagnosis and treatment of bronchial asthma.
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