早期高压氧联合标准大骨瓣开颅术治疗重型颅脑外伤的临床效果

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Abstract Objective To study the clinical effect of early hyperbaric oxygen combined with standard large trauma craniotomy in the treatment of patients suffered from severe traumatic brain injury. Methods The clinical data of 70 cases with severe traumatic brain injury in Hebei People′s Hospital from March 2013 to January 2016 was analyzed retrospectively. 35 cases of control group received standard large trauma craniotomy treatment and 35 cases of observation group received early hyperbaric oxygen combined with standard large trauma craniotomy treatment. The recovery conditions of disease of the two groups were assessed by Glasgow coma scale (GCS) before treatment and after treatment for 4 months; the nerve function indices in serum and amino acid neurotransmitters were measured by enzyme-linked immunosorbent assay (ELISA). Results The GCS scores, serum nerve function indices [nerve growth factor (NGF), glial fibrillary acidic protein (GFAP), S-100B protein (S-100B)], and the contents of amino acid neurotransmitters [glutamic acid (Glu), γ-aminobutyric acid (GABA), aspartic acid (Asp), glycine (Gly)] of both groups after treatment were significantly improved compared with those before treatment (P ＜ 0.05), and the improvement of the indices above in the observation group was significantly higher than those of the control group, the differences between the two groups were statistically significant (P ＜ 0.05). Conclusion Early hyperbaric oxygen combined with standard large craniotomy can improve the efficacy of patients with severe traumatic brain injury, optimize the nerve function and inhibit the toxic effect of excitatory amino acids.

Key words： Severe traumatic brain injury Hyperbaric oxygen Standard large trauma craniotomy

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	YANG Jun ZHANG Pinyuan WU Yang ZHANG Kuo QIAN Tao▲

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YANG Jun ZHANG Pinyuan WU Yang ZHANG Kuo QIAN Tao▲. Clinical effect of early hyperbaric oxygen combined with standard large trauma craniotomy in the treatment of severe traumatic brain injury[J]. 中国医药导报, 2017, 14(35): 58-61.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I35/58

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