血清C1q、超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性研究

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Abstract Objective To explore the correlation between serum C1q, hypersensitive C-reactive protein(hs-CRP) and coronary atherosclerotic heart disease(CHD). Methods From October 2016 to April 2017, 406 clinical data of patients treated in the Department of Cardiology, Dongfeng General Hospital, Hubei University of Medicine were analyzed retrospectively and divided into the control group (200 cases) and the CHD group (206 cases) according to the history of percutaneous coronary intervention coronary angiography or whether the coronary artery stenosis was greater than 50% by coronary angiography. The levels of C1q and hs-CRP were compared between the two groups. The risk factors of CHD were analyzed by Logistic regression analysis. Results The serum C1q in the CHD group was lower than that of control group, and the hs-CRP in the CHD group was higher than that of control group, with statistically significant differences (P ＜ 0.05). Logistic regression analysis indicated that in the coronary heart disease group the age (OR = 1.036, 95%CI =1.009-1.064, P ＜ 0.05), diabetes (OR = 4.629, 95%CI = 2.159-9.924, P ＜ 0.05), LDL-C (OR = 2.965, 95%CI = 1.286-6.835, P ＜ 0.05), Glu (OR = 1.033, 95%CI = 1.246-1.856, P ＜ 0.05), hs-CRP (OR = 1.509, 95%CI = 1.225-1.859, P ＜ 0.05) were the risk factors for CHD and the C1q (OR = 0.991，95%CI = 0.983-0.998，P ＜ 0.05) was the protective factor. Conclusion Serum C1q is the protective factor and hs-CRP is the risk factor in CHD and both can be used as clinically reliable diagnosis and evaluation index for CHD.

Key words： Coronary heart disease Serum C1q Hypersensitive C-reactive protein

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	CHEN Xiaoqiang YANG Handong CHEN Jun

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CHEN Xiaoqiang YANG Handong CHEN Jun. The correlation study between serum C1q, high sensitivity C-reactive protein and coronary atherosclerotic heart disease[J]. 中国医药导报, 2017, 14(35): 41-44,49.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I35/41

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