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| Characteristics of thyroid hormone changes and their correlation with albumin in patients with schizophrenia |
| ZHAI Yuanyuan1 ZHANG Hui2 MA Jin1 AO Lei4 ZHANG Yan3 |
1.Clinical Laboratory, Xi′an Mental Health Center, Shaanxi Province, Xi′an 710100, China;
2.Medical Department, Xi′an Mental Health Center, Shaanxi Province, Xi′an 710100, China;
3.Pharmaceutical Laboratory, Xi′an Mental Health Center, Shaanxi Province, Xi′an 710100, China;
4.the Second Division of Women′s Mental Health, Xi′an Mental Health Center, Shaanxi Province, Xi′an 710100, China |
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Abstract Objective To investigate the change characteristics of serum thyroid hormone and its correlation with albumin (ALB) in patients with schizophrenia. Methods Eighty patients with schizophrenia admitted by the outpatient department of Xi′an Mental Health Center were selected as the disease group, and forty-six healthy patients from Xi′an Friendship Hospital were selected as the control group. Serum levels of thyrotrophin (TSH), triiodinated thyroxine (T3), thyroxine (T4), free triiodinated thyroxine (FT3), free thyroxine (FT4), and reverse triiodothyronine (rT3) in two groups were detected by chemical radiometry. At the same time, the ALB level of patients in the disease group was detected by the end point method of bromocresol purple. Results TSH, FT4 and rT3 levels in the disease group were all higher than those in the control group, while T3 and FT3 levels were lower than those in the control group, with statistically significant differences (P ＜ 0.05). There was no significant difference in T4 between the two groups (P ＞ 0.05). There were no statistically significant differences in the effects of disease course and gender on thyroid hormone indexes (TSH, T3, T4, FT3, FT4, rT3, T3/rT3) in the disease group (all P ＞ 0.05). In the disease group, the T3/rT3 ratio was negatively correlated with ALB level (r = -0.262，P = 0.019). Conclusion In schizophrenia patients with thyroid dysfunction, rT3 elevation is the characteristic change, and the T3/rT3 ratio is negatively correlated with ALB level.
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