血清CyPA、Lp-PLA2水平与急性脑梗死患者病情的关系

Abstract
Figure/Table
References (22)
Related Citation (15)

Download: PDF (731 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the levels and the clinical significant of serum cyclophilin A (CyPA), lipoprotein associated phospholipase A2 (Lp-PLA2) in patients with acute cerebral infarction. Methods A total of 117 patients with acute cerebral infarction admitted to Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine (hereinafter referred to as “our hospital”) from January 2016 to June 2018 were enrolled as case group, who were divided into slight group (NIHSS ＜7 scores, n = 51), moderate group (NIHSS 7-15 scores, n = 37), severe group (NIHSS ＞15 scores, n = 29) according to national institute of health stroke scale (NIHSS score). At the same time, 60 healthy examinees in our hospital were selected as control group. The serum CyPA and Lp-PLA2 of each groups were determined by enzyme-linked immunosorbent assay, and serum Cystatin C (CysC), homocysteine (Hcy) and uric acid (UA) were determined by granule immunoturbidimetry. Results The levels of serum CyPA and Lp-PLA2 in case group were higher than those in control group, and the levels of serum CyPA, Lp-PLA2 gradually increased with the condition worsened (P ＜ 0.05). The levels of serum CysC, Hcy, UA in case group were higher than those in control group, and the levels of serum CysC, Hcy, UA gradually increased with the condition worsened (P ＜ 0.05). Pearson product moment correlation analysis showed that serum CyPA was positive associated with Lp-PLA2 (r = 0.761, P ＜ 0.05). CyPA was positively correlated with CysC, Hcy and UA (r = 0.679, 0.625, 0.702, all P ＜ 0.05), Lp-PLA2 was positively correlated with CysC, Hcy and UA (r = 0.738, 0.711, 0.692, all P ＜ 0.05). Conclusion Serum CyPA and Lp-PLA2 are closely related to the severity of acute cerebral infarction. Early detection of CyPA and Lp-PLA2 has clinical value in evaluating patients′ condition.

Key words： Acute cerebral infarction Cyclophilin A Lipoprotein associated phospholipase A2 Clinical significance

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	KANG Yi1 MA Yu2 LU Liuxi2 ZHAN Qunling2

Cite this article:

KANG Yi1 MA Yu2 LU Liuxi2 ZHAN Qunling2. Relationship between serum CyPA, Lp-PLA2 levels and disease status in patients with acute cerebral infarction[J]. 中国医药导报, 2019, 16(35): 123-126.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I35/123

[1] Iso T，Yanagawa Y，Takeuchi I，et al. Concomitance Acute Cerebral Infarction and Remote Intra-Cerebral Hemorrhaging on Arrival [J]. J Emerg Trauma Shock，2018，11（2）：149-150.
[2] Xu R，Yin X，Xu W，et al. Assessment of carotid plaque neovascularization by contrast-enhanced ultrasound and high sensitivity C-reactive protein test in patients with acute cerebral infarction：a comparative study [J]. Neurol Sci，2016，37（7）：1107-1112.
[3] Goncalves I，Edsfeldt A，Kon Y，et al. Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation [J]. Arteroscler Thromb Vasc Biol，2012，32（12）：1505-1512.
[4] Flaherty ML，Kissela B，Khoury JC，et al. Carotid artery stenosis as a cause of stroke [J]. Neuroepidemiology，2013，40（1）：36-41.
[5] Dawar FU，Xiong Y，Khattak MNK，et al. Potential role of cyclophilin A in regulating cytokine secretion [J]. J Leukoc Biol，2017，102（4）：989-992.
[6] Cojocaru IM，Cojocaru M，Tnsescu R，et al. Phospholipase A2 in patients with noncardioembolic ischemic stroke and severe inflammatory reaction [J]. Rom J Inter Med，2009， 47（1）：61-65.
[7] 中华神经科学会，中华神经外科学会.各类脑血管病诊断要点[J].中华神经科杂志，1996，29（6）：379-381.
[8] Kaschner MG，Caspers J，Rubbert C，et al. Mechanical thro-mbectomy in MCA-mainstem occlusion in patients with low NIHSS scores [J]. Interv Neuroradiol，2018，24（4）：398-404.
[9] Kim J，Song TJ，Song D，et al. Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction [J]. Stroke，2013，44（12）：3547-3549.
[10] Yamamoto N，Satomi J，Yamamoto Y，et al. Risk Factors of Neurological Deterioration in Patients with Cerebral Infarction due to Large-Artery Atherosclerosis [J]. J Stroke Cerebrovasc Dis，2017，26（8）：1801-1806.
[11] 张田田，张俊峰.亲环素A及其受体CD147对动脉粥样硬化的影响[J].上海交通大学学报：医学版，2011，31（12）：1778-1781.
[12] Tian-Tian Z，Jun-Feng Z，Heng G. Functions of cyclophilin A in atherosclerosis [J]. Exp Clin Cardiol，2013，18（2）：e118-e124.
[13] 王茂林，汪恩焕，周钟阳，等.血清亲环素A与急性动脉粥样硬化性脑梗死关系研究[J].淮海医药，2014，32（3）：221-222.
[14] Bonnefont-Rousselot D. Lp-PLA2，a biomarker of vascular inflammation and vulnerability of atherosclerosis plaques [J]. Ann Pharm Fr，2016，74（3）：190-197.
[15] Pokharel Y，Sun W，Polfus LM，et al. Lipoprotein associated phospholipase A2 activity，apolipoprotein C3 loss-of-function variants and cardiovascular disease：The Athe-rosclerosis Risk In Communities Study [J]. Atherosclerosis，2015，241（2）：641-648.
[16] Mitra S，Goyal T，Mehta JL. Oxidized-LDL，LOX 1 and atherosclerosis [J]. Cardiovasc Drugs Ther，2011，25（4）：419.
[17] Oei HH，Vander Meer IM，Hofman A，et al. Lipoprotein-associated phospholipae A2 activity is associated with risk of coronary heart disease and ischemic stroke：the Rotterdam Study [J]. Circulation，2005，111（6）：570-575.
[18] 林俐红，查显丰，李珉珉，等.急性脑梗死患者血清Lp-PLA2he hs-CRP检测的临床意义[J].暨南大学学报：自然科学与医学版，2016，37（1）：66-69.
[19] 张蓉.急性脑梗死患者血浆胱抑素C、同型半胱氨酸水平与颈动脉粥样硬化的相关性分析[J].实用心脑肺血管病杂志，2014，22（10）：28-31.
[20] 李伟周.高同型半胱氨酸血症对急性脑梗死患者尿激酶静脉溶栓治疗效果的影响[J].中国医药导报，2017， 14（25）：54-57.
[21] Wu W，Guan Y，Xu Y，et al. Plasma homocysteine levels predict the risk of acute cerebral infarction in patients with carotid artery lesions [J]. Mol Neurobiol，2016，53（4）：2510-2517.
[22] 刘玲，陈晴清，李华，等.急性脑梗死患者血清尿酸水平与颈动脉粥样硬化斑块相关性研究[J].临床急诊杂志，2016，17（3）：175-178.