宫颈病变患者外周血T淋巴细胞亚群、调节性T细胞的表达变化及临床意义

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Abstract Objective To explore the expression changes of T lymphocyte subsets and regulatory T cells in peripheral blood of patients with cervical lesions and its clinical significance. Methods From January 2017 to June 2019, 100 cases with cervical lesions admitted to Zhenjiang Fourth People′s Hospital were selected as case group. According to the types of cervical lesions, they were divided into chronic cervicitis subgroup (n = 24), cervical intraepithelial neoplasia subgroup (n = 37) and cervical cancer subgroup (n = 39). According to the infection of human papillomavirus (HPV), They were divided into HPV high-risk subgroup (n = 58) and HPV low-risk subgroup (n = 42). In the same period, 65 cases with healthy volunteers were randomly selected as control group. The expression of T lymphocyte subsets and regulatory T cells in peripheral blood of each groups were detected by the flow cytometry. Results The levels of CD3+, CD4+, CD4+/CD8+ in case group were lower than those in control group, and the levels of CD8+, CD4+CD25+CD127- were higher than those in control group, and the differences were statistically significant (all P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ in cervical intraepithelial neoplasia subgroup and cervical cancer subgroup were lower than those in chronic cervicitis subgroup, and the levels of CD8+, CD4+CD25+CD127- were higher than those in chronic cervicitis subgroup, and the differences were statistically significant (all P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ in cervical cancer subgroup were lower than those in cervical intraepithelial neoplasia subgroup, and the levels of CD8+, CD4+CD25+CD127- were higher than those in cervical intraepithelial neoplasia subgroup, and the differences were statistically significant (all P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+ in HPV high-risk subgroup were lower than those in HPV low-risk subgroup, and the levels of CD8+, CD4+CD25+CD127- were higher than those in HPV low-risk subgroup, and the differences were statistically significant (all P < 0.05). Pearson accumulates correlation analysis showed that the severity of cervical lesions in patients was negatively associated with CD3+ (r = -0.617， P < 0.05), CD4+ (r = -0.592， P < 0.05), CD4+/CD8+ (r = -0.628， P < 0.05), and positively associated with CD8+ (r = 0.603，P < 0.05), CD4+CD25+CD127- (r = 0.624，P < 0.05). Conclusion The abnormal expression of T lymphocyte subsets and regulatory T cells in peripheral blood of patients with cervical lesions is closely related to the severity of cervical lesions and the risk of HPV infection.

Key words： Cervical lesions T lymphocyte subsets Regulatory T cell Clinical significance

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	XIA Liangping LIU Dabiao

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XIA Liangping LIU Dabiao. Expression changes of T lymphocyte subsets and regulatory T cells in peripheral blood of patients with cervical lesions and its clinical significance[J]. 中国医药导报, 2019, 16(35): 90-93.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I35/90

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