Th17/Treg失衡与肺部疾病发病机制的研究进展

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Abstract T helper 17 cells (Th17) with pro-inflammatory activity and regulatory T cells (Treg) cells that maintain immune tolerance are important immune cells in humans. They are closely related in differentiation and functional constraints to each other, and there is a dynamic balance. Imbalance between the two can lead to autoimmune diseases, tumors, persistent infection diseases. In recent years, with the study of the common diseases of the respiratory system deeply, of Th17 cells and Treg cells were found to be associated with more lung disease pathogenesis, immune imbalance of Th17/Treg cells in patients with chronic obstructive pulmonary disease, lung cancer, pulmonary sarcoidosis and asthma among the adjustment mechanism. This article describes the progress of Th17 cells, Treg cells and Th17/Treg imbalance in lung related diseases.

Key words： T helper 17 cells Regulatory T cells Pulmonary disease Research progress

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	ZHANG Yi1
	2 ZHANG Lanying1 OUYANG Yao1

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ZHANG Yi1,2 ZHANG Lanying1 OUYANG Yao1. The research progress of Th17/Treg imbalance in pathogenesis of pulmonary disease[J]. 中国医药导报, 2017, 14(35): 20-24.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I35/20

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