针药联合治疗高血压合并动脉粥样硬化的临床观察

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Abstract Objective To observe the clinical effect of Yangmai Huatan Decoction combined with acupuncture in the treatment of hypertension with atherosclerosis. Methods From June 2017 to September 2018, 100 cases of vertigo patients were selected from the outpatient department and ward of Department of Acupuncture and Moxibustion, Heilongjiang Academy of Sciences of Traditional Chinese Medicine. The patients were divided into combined treatment group and control group, each group with 50 cases. The final effective cases were 84 cases, 43 cases in combined treatment group and 41 cases in control group. The patients in control group were treated with Western medicine standardized antihypertensive, antiplatelet, hypolipidemic and other symptomatic treatment. On this basis, the patients in combined treatment group were treated with Yangmai Huatan Decoction and acupuncture. Patients of two groups were treated continuously for two months. Before and after treatment, blood pressure, arterial media thickness (IMT), resistance index (RI), serum anti oxidant and inflammatory factors were observed in two groups. Results The levels of systolic and diastolic blood pressure in two groups were lower than those before treatment, the difference was statistically significant (P < 0.05). IMT of bilateral common carotid artery in two groups after treatment was thinner than that before treatment, and the change in combined treatment group was more significant than that in control group, the difference was statistically significant (P < 0.05). RI of bilateral renal arteries in two groups after treatment was lower than that before treatment, and the change in combined treatment group was more significant than that in control group, the difference was statistically significant (P < 0.05). Levels of superoxide dismutase and malondialdehyde in two groups after treatment were higher than those before treatment, the levels of tumer necrosis faltor-α and interleukin-6 were lower than those before treatment, and the changes in combined treatment group were more significant than those in control group, the difference was statistically significant (P < 0.05). Conclusion The combination of acupuncture and medicine can effectively delay the progression of atherosclerosis in patients with hypertension, which is significantly better than western medicine alone in reducing blood pressure, lipid and antiplatelet therapy. This therapeutic effect is independent of the decrease of blood pressure, and may play a therapeutic effect by inhibiting the inflammatory response and oxidative stress injury in patients.

Key words： Hypertension Atherosclerosis Inflammatory response Acupuncture and medicine combination Oxidative stress

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	LIANG Hao1
	2 YU Ying1 ZHOU Zhongguang1

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LIANG Hao1,2 YU Ying1 ZHOU Zhongguang1. Clinical observation of acupuncture combined with medicine in the treatment of hypertension with atherosclerosis[J]. 中国医药导报, 2019, 16(30): 147-150,167.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I30/147

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