宫颈疾病患者HPV感染分型及微量元素检测分析

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Abstract Objective To investigate the typing of human papillomavirus (HPV) infection in patients with cervical diseases and the effect of trace elements. Methods From December 2017 to December 2018, 600 patients with abnormal cervical cytology admitted to Chengde Central Hospital in Hebei Province were selected as the study group, and 360 patients with chronic cervicitis at the same time were selected as the control group. HPV typing and serum trace elements levels were compared and the clinical characteristics of HPV typing and serum trace elements in patients with cervical diseases were analyzed. Results The positive rate of HPV in the study group was higher than that in the control group (P < 0.05). The types of HPV in the study group were HPV18, 16, 31, 33, 52, 58, 59, 6. The types of HPV in the control group were HPV33, 52, 58, 66, 68, 6, 11, 43. The positive rate of high-risk HPV in the study group was higher than that in the control group. HPV infection types was compared between two groups, the difference was statistically significant (P < 0.05). Spearman correlation analysis showed that cervical cytology abnormalities were positively correlated with HPV infection and high-risk HPV infection (r = 0.403, 0.468, all P < 0.05) . The positive rate of single infection in the study group was higher than that in the control group (P < 0.05). The levels of serum cadmium, nickel, arsenic and copper in the study group were higher than those in the control group, the levels of serum zinc and selenium in the study group were lower than those in the control group, the differences were highly statistically significant (P < 0.01). Logistic regression analysis showed that copper > 28.73 μmol/L was an independent risk factor for cervical cytological abnormalities, while zinc > 71.96 μmol/L and selenium > 36.47 μg/L had protective effects (P < 0.01). Conclusion Cervical cytological abnormalities in patients with cervical diseases are closely related to HPV infection typing, serum zinc, selenium and copper levels.

Key words： Cervical diseases Cervical cancer Precancerous lesions Human papillomavirus Trace elements

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	SI Baihui1 LIU Haixia1 SI Fan2 WAN Hui1

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SI Baihui1 LIU Haixia1 SI Fan2 WAN Hui1. Analysis on type of HPV infection and detection of trace elements in patients with cervical diseases[J]. 中国医药导报, 2019, 16(30): 106-109.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I30/106

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