妊娠期糖尿病对新生儿脐带血血气分析的影响

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Abstract Objective To investigate the effect of gestational diabetes mellitus (GDM) on blood gas analysis in neonates. Methods A total of 2913 GDM and 3216 non-GDM women with single pregnancy in Foshan Women and Children′s Hospital from January 2017 to August 2018 were randomly sampled and collected. All indexes of neonatal umbilical cord blood were tested by blood gas electrolyte analyzer, and further analyzed between groups and subgroups, including subgroups of blood glucose abnormality at different time point of oral glucose tolerance test (OGTT) and subgroups of delivery mode. Results The results of base excess extracellular fluid (BEecf), BEblood (BEb), standard bicarbonate concentration (SBC), total carbon dioxide (TCO2), partial pressure of carbon dioxide (PCO2) and sodium (Na+) between GDM group and non-GDM group were compared, and the differences were tstatistically significant (P < 0.05). There were significant difference in BEecf, BEb, TCO2, partial alveolar arterial oxygen pressure (A-aDO2) and Na+ among GDM neonates with abnormal blood glucose at different time points of OGTT (P < 0.05). In addition to oxygen partial pressure (PO2), oxyhemoglobin saturation (SaO2) and Na+ between GDM cesarean section group and GDM vaginal delivery group, there were significant differences in other detection indexes (P < 0.05). Conclusion Under the ideal condition of blood glucose control in GDM pregnant women, BEb, TCO2 and SBC changed, but not enough to affect the pH value of umbilical cord blood, and had no significant effect on PO2 and SaO2.

Key words： Gestational diabetes mellitus Blood gas analysis Pregnancy outcome Neonatal outcome

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	SUO Dongmei ZHOU Zixing LIU Juan GUO Qileng LI Weiling

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SUO Dongmei ZHOU Zixing LIU Juan GUO Qileng LI Weiling. Effect of gestational diabetes mellitus on blood gas analysis of neonatal umbilical cord[J]. 中国医药导报, 2019, 16(30): 101-105.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I30/101

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