MRP 8/14与2型糖尿病患者的甲状腺功能的相关性

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Abstract Objective To analyze the correlation between MRP 8/14 and thyroid hormone in patients with type 2 diabetes mellitus. Methods Eighty patients with type 2 diabetes mellitus admitted to the Department of Endocrine Metabolism, the Affiliated Huai′an No.1 People′s Hospital of Nanjing Medical University from December 2014 to September 2016 were collected. According to the median of MRP 8/14, they were divided into group A (MRP 8/14≤5.41 μg/mL) and group B (MRP 8/14 ＞5.41 μg/mL), with 40 patients in each group. The gender, age, body mass index (BMI), duration of diabetes, systolic blood pressure, diastolic blood pressure, fasting blood glucose, glycosylated hemoglobin (HbA1c), total cholesterol, triacylglycerol, low density lipoprotein cholesterin, high density lipoprotein cholesterin, serum creatinine and urinary albumin/creatinine ratio (ACR), thyroid stimulating hormone (TSH), thyroid hormone [serum free triiodine-methylamine (FT3), serum free thyroxine (FT4)], MRP 8/14 and other clinical data of all participants were recorded and analyzed. Results There were no statistically significant differences in gender, age, BMI, duration of diabetes, systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, total cholesterol, triacylglycerol, low density lipoprotein cholesterin, high density lipoprotein cholesterin, FT3, FT4 between the two groups (all P ＞ 0.05). Serum creatinine, ACR and TSH in group A were significantly lower than those in group B (all P ＜ 0.05). Serum MRP 8/14 level was positively correlated with BMI, systolic blood pressure, serum creatinine, ACR and TSH (P ＜ 0.05). Conclusion Serum MRP 8/14 is positively correlated with TSH level in patients with type 2 diabetes mellitus, so MRP 8/14 may be involved in thyroid hormone changes in patients with type 2 diabetes mellitus

Key words： Type 2 diabetes mellitus Serum myeloid-related protein-8/14 Thyroid hormone

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	GU Wensha SHI Min XU Wendong ZHANG Hong

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GU Wensha SHI Min XU Wendong ZHANG Hong. Correlation Between MRP 8/14 and thyroid hormone in patients with type 2 diabetes mellitus[J]. 中国医药导报, 2019, 16(30): 62-65.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I30/62

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