载脂蛋白E基因多态性检测在脑梗死中的意义

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Abstract Objective To investigate the correlation between the gene polymorphism of apolipoprotein E (ApoE) and the development of cerebral infarction. Methods The case group of 348 patients with cerebral infarction in Neurology Department of the First People′s Hospital of Foshan ("our hospital" for short) from January 2015 to March 2017, and control group of 352 healthy people at the same time in our hospital were selected. Both groups were used the gene chip approach for the ApoE genotype tested. ApoE genotype and phenotype between the two groups, and the serum lipid levels of patients with different ApoE gene phenotypes were compared. Results The highest genotype frequency of ApoE was ε3/3 and the highest allele frequency was ε3 in the two groups. The ε2/3 and ε3/3 genotypes in the case group were significantly lower than the control group, the differences were statistically significant (P < 0.05); and the ε3/4 was significantly higher than the control group, the difference was highly statistically significant (P < 0.01). The frequency of ε2 allele in case group was significantly lower than the control group, the difference was statistically significant (P < 0.05), while the ε4 was significantly higher than the control group, the difference was highly statistically significant (P < 0.01). Compared with the levels of blood lipids in different ApoE phenotypes patients of the case group, the levels of total cholesterol and low density lipoprotein cholesterin were the lowest in E2 genotype patients, the differences were statistically significant (P < 0.05). Conclusion The ApoE gene polymorphism plays an important role in the occurrence and development of cerebral infarction.

Key words： Apolipoprotein E Cerebral infarction Gene polymorphism Serum lipid

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	LI Meizhu ZHU Changlin CHEN Binhong LI Weixuan

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LI Meizhu ZHU Changlin CHEN Binhong LI Weixuan. The significance of apolipoprotein E gene polymorphism in cerebral infarction[J]. 中国医药导报, 2017, 14(34): 110-113.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I34/110

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