血清25羟维生素D、瘦素水平与女性绝经后2型糖尿病患者骨密度的关系

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Abstract Objective To analyze the relationship between serum 25-hydroxyvitamin D [25(OH)D], leptin levels and bone metabolism in postmenopausal women with type 2 diabetes mellitus. Methods The clinical data of 80 patients with postmenopausal type 2 diabetes mellitus treated in Nanjing Gulou Hospital from June 2014 to November 2018 was retrospectively analyzed. According to the bone mineral density level, the patients were divided into osteoporosis group (28 cases), osteopenia group (27 cases) and normal bone mass group (25 cases). The serum 25 (OH)D, leptin levels and serum bone metabolic indexes in each group were measured. The relationship between serum 25 (OH)D, leptin levels and bone metabolism in postmenopausal women with type 2 diabetes mellitus was analyzed. Results Compared with the normal bone mass group, the serum 25 (OH)D levels in osteoporosis group and osteopenia group decreased (P ＜ 0.05), and the serum 25 (OH)D level in osteoporosis group was lower than that in osteopenia group (P ＜ 0.05). The serum leptin levels in osteoporosis group and osteopenia group were higher than those in normal bone mass group (P ＜ 0.05), which in osteoporosis group was higher than that in osteopenia group (P ＜ 0.05). There were no significant differences of serum Ca and P levels among the three groups (P ＞ 0.05). The levels of serum beta C-terminal cross-linked telopeptides of typeⅠcollagen (β-CTX), bone gla protein (BGP) and procollagen typeⅠamino-terminal propeptide (PINP) in osteoporosis group and osteopenia group were higher than those in normal bone mass group (P ＜ 0.05), and the levels of serum indicators in osteoporosis group were higher than those in osteopenia group, the differences were statistically signiigfcicant (P ＜ 0.05). Spearman correlation analysis showed that bone mineral density was positively correlated with serum 25 (OH)D (r = 0.142, P = 0.036), negatively correlated with serum leptin (r = -0.325, P = 0.000), β-CTX (r = -0.135, P = 0.001), BGP (r = -0.183, P = 0.000), PINP (r = -0.106, P = 0.002). Conclusion Bone mineral density is positively correlated with serum 25 (OH)D level and negatively correlated with serum leptin in postmenopausal patients with type 2 diabetes mellitus.

Key words： Postmenopausal type 2 diabetes mellitus Bone metabolism 25-hydroxyvitamin D Leptin

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	HUANG Liang LU Bangchao

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HUANG Liang LU Bangchao. The relationship between serum 25-hydroxyvitamin D, leptin levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus[J]. 中国医药导报, 2019, 16(29): 132-135.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I29/132

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