双相抑郁障碍患者的认知功能及比率低频振幅研究

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Abstract Objective To investigate the characteristics and correlation of cognitive function and the fractional amplitude of low frequency fluctuation (fALFF) in patients with bipolar depression. Methods From December 2017 to March 2019, 26 patients with bipolar depression who were treated in the Brain Hospital Affiliated to Nanjing Medical University were selected as the bipolar depression group, and 26 well-matched healthy people with gender, age and education level were recruited as the control group. All subjects were assessed for cognitive function and received MRI scans to collect resting state MRI data and obtain fALFF values. Correlation analysis were performed between fALFF values of significant brain regions and cognitive function in bipolar depression patients. Results Compared with the control group, the speed of processing, working memory, reasoning and problem solving, visual learning, attention/vigilance in the bipolar depression group performed poorly (all P < 0.05). The fALFF values of the bipolar depression group increased significantly in the left postcentral gyrus, the left precentral gyrus, the right postecentral gyrus, the left inferior parietal lobule, the right superior temporal gyrus, the right opercular part of inferior frontal gyrus and the right precuneus (all P < 0.005, TFCE corrected). The fALFF value of the left precentral gyrus in the bipolar depression group was positively correlated with category fluency (r = 0.73, TFCE corrected). Conclusion Cognitive dysfunction in most cognitive fields and abnormal neurological activity in multiple brain regions exist in the bipolar depression group, and abnormal neurological activity in specific brain regions is related to neurocognitive performance.

Key words： Bipolar depressions Resting-state functional magnetic resonance imaging Fractional amplitude of low frequency fluctuation Cognitive function

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	LYU Lanlan ZHANG Rongrong YAN Wei NI Longyan PENG Xiaohui XIE Shiping

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LYU Lanlan ZHANG Rongrong YAN Wei NI Longyan PENG Xiaohui XIE Shiping. Study on cognitive function and fractional amplitude of low frequency fluctuation in patients with bipolar depression[J]. 中国医药导报, 2019, 16(29): 76-79,91.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I29/76

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