|
|
|
| Clinical study of Yiqi Huayu Recipe in the treatment of Hashimoto thyroiditis with normal thyroid function |
| LUO Yuanlin SHAO Yingxin▲ ZHOU Tao JIANG Chao |
| Department of Thyroid, Huanggang Hospital of Traditional Chinese Medicine, Hubei Province, Huanggang 438000, China |
|
|
|
|
Abstract Objective To observe the effects of Yiqi Huayu Recipe on the thyroid autoantibodies and thyroid function in Hashimoto thyroiditis (HT) patients with normal thyroid function. Methods From July 2016 to February 2017, a total of 112 patients of HT with normal thyroid function in Department of Thyroid, Hubei Huanggang Hospital of Traditional Chinese Medicine, were recruited in this study. They were randomly classified into treatment group and control group, with 56 cases in each group. The treatment group was given Chinese medicine compound preparation of Yiqi Huayu Recipe, the control group did not take any medication, they were only taken iodine deficient diet. The two groups were treated for 6 months, The thyroid autoantibodies [thyroid peroxidase antibody (TPOAb), thyroglobulin antibodies (TgAb)] and thyroid function [thyrotropic hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4)] were measured before and after treatment. Results The levels of TPOAb and TgAb in the treatment group were both lower than those before treatment, the differences were statistically significant (P ＜ 0.05), which were significantly lower than those of control group (P ＜ 0.05); the levels of TPOAb and TgAb in the control group were significantly higher than those before treatment, the differences were statistically significant (P ＜ 0.05). After treatment, the level of TSH in the control group was significantly higher than that before treatment, which was significantly higher than that of treatment group (P ＜ 0.05), there was no statistically significant difference of TSH in the treatment group before and after treatment (P ＞ 0.05). There were no statistically significant differences of FT3 and FT4 before and after treatment in the two groups (P ＞ 0.05). Conclusion Chinese medicine compound preparation of Yiqi Huayu Recipe can reduce the levels of TPOAb and TgAb in HT patients with normal thyroid function, but it has little effects on thyroid function; iodine deficient diet can not control the increase of TPOAb, TgAb and TSH in HT patients.
|
|
|
|
|
|
[1] 汪虹，江潮，邵迎新.桥本甲状腺炎诊断及治疗研究进展[J].黑龙江医学，2015，35（3）：230-232.
[2] 中华医学会内分泌学分会.中国甲状腺疾病诊治指南[J].中华内科杂志，2008，47（9）：784-788.
[3] 江潮，周涛，邵迎新，等.桥本甲状腺炎的中医治疗策略[J].中国医药导报，2016，12（8）：9-11.
[4] 刘超，杨昱，陈立立.甲状腺自身抗体的基础和临床进展[J].内科理论与实践，2010，5（2）：139-146.
[5] 施秉银.硒对甲状腺影响的探索与发现[J].中华内分泌代谢杂志，2016，32（1）：4-5.
[6] 朱辉，刘超，蔡可英.甲状腺功能减退症替代治疗：使用左旋甲状腺素是否充足？[J].中华内分泌代谢杂志，2015， 31（4）：296-299.
[7] 刘正云，张克勤.甲状腺过氧化物酶抗体阳性孕妇妊娠结局的初步研究[J].中华内分泌代谢杂志，2015，31（12）：1041-1045.
[8] 闫慧娴，谷伟军，杨国庆，等.桥本甲状腺炎与甲状腺乳头状癌关系的临床研究[J].中华内分泌代谢杂志，2014， 30（4）：302-306.
[9] 陈如泉，左新河.甲状腺病中医学术源流与研究[M].北京：人民卫生出版社，2016.
[10] 胡国庆，陈筑红.疏肝散结方治疗初发甲状腺功能正常桥本甲状腺炎疗效分析[J].中国药业，2015，24（21）：105-107.
[11] 钟欣婵，郑敏，张强，等.疏肝清热方治疗桥本甲状腺炎患者40例临床观察[J].中医杂志，2016，57（2）：145-148.
[12] 杜鸣，汪虹，邵迎新.自拟方对桥本甲状腺炎患者甲状腺球蛋白抗体、甲状腺过氧化物酶抗体的影响[J].国际中医中药杂志，2014，36（5）：419-421.
[13] 陈思兰，李桂芹，林兰.补肾健脾疏肝法治疗慢性淋巴细胞性甲状腺炎探讨[J].国际中医中药杂志，2013，35（9）：860-861.
[14] 梁栋，赵晓杰.清瘿化痰汤治疗桥本甲状腺炎肝郁痰凝证临床观察[J].山东中医杂志，2016，35（7）：594-597.
[15] 徐蓉娟，葛芳芳.“病证结合”辨治桥本甲状腺炎[J].上海中医药大学学报，2016，30（1）：1-3.
[16] 陈继东，赵勇，裴迅，等.中药方治疗桥本甲状腺炎疗效的Meta分析[J].中华中医药学刊，2016，34（4）：833-837.
[17] 董玥，王秀民，赵磊，等.疏肝健脾法配合优甲乐治疗桥本甲状腺炎的研究[J].现代中西医结合杂志，2016，25（24）：2639-2641.
[18] 范尧夫，刘克冕，张会峰，等.中西医结合治疗桥本甲状腺炎甲状腺功能减退的Meta分析[J].中国实验方剂学杂志，2016，21（3）：221-224.
[19] 王秋虹，魏军平，王师菡，等.林兰教授中西医结合治疗桥本甲状腺炎经验撷菁[J].环球中医药，2015，8（3）：352-354.
[20] 叶玉峰，江潮，邵迎新，等.益气化瘀法在自身免疫性甲状腺疾病中的应用[J].中国医药导报，2016，13（10）：80-83.
[21] 汪虹，曹钟，邵迎新.1239例甲状腺结节回顾性分析并文献复习[J].现代肿瘤医学，2015，23（7）：921-925.
[22] 王小龙，高城翰，高天舒，等.辨体辨证治疗甲状腺功能正常桥本甲状腺炎[J].环球中医药，2015，8（11）：1397-1399. |
|
|
|
