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| Clinical effect of Alprostadil on ARDS patients with septic shock |
| WANG Zhi LIU Ye TENG Le MENG Xing |
| Department of Critical Care Medicine, PLA 964th Hospital, Jilin Province, Changchun 130062, China |
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Abstract Objective To investigate the clinical effect of Alprostadil on septic shock with acute respiratory distress syndrome (ARDS). Methods From February 2015 to November 2018, 81 cases of ARDS with infectious shock in PLA 964th Hospital were selected, patients were randomly divided into control group (n = 40) and study group (n = 41) by random numerber table method. The control group was given conventional treatment, and the study group was treated with Alprostadil on the basis of the control group. Clinical indicators, respiratory function indicators and inflammatory factor indicators of the two groups were compared, and adverse reactions in the two groups during treatment were recorded. Results Mechanical ventilation duration, length of stay in ICU and total length of stay in the study group were shorter than those in the control group (P ＜ 0.05). However, there was no statistically significant difference in mortality between the two groups (P ＞ 0.05). OI and PaO2 showed a trend of increase and RR showed a trend of decrease after 2 and 3 days of treatment (P ＜ 0.05). RR in the study group was lower than that in the control group after treatment for 2 and 3 d, while PaO2 and OI were higher than that in the control group (P ＜ 0.05). The levels of interleukin-6, procalcitonin, C-reactive protein and tumor necrosis factor-α in both groups decreased after 3 d of treatment, and the levels in the study group were lower than those in the control group (P ＜ 0.05). The difference in adverse reactions between the two groups was no statistically significant (P ＞ 0.05). Conclusion Alprostadil can effectively improve mechanical ventilation time, length of ICU stay, and total length of stay in ARDS patients with septic shock without increasing the incidence of adverse reactions, which may be related to the improvement of respiratory function and inflammatory response.
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