丹参注射液辅助常规疗法治疗口腔黏膜下纤维性变的效果及对SFRP1水平的影响

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Abstract Objective To explore the therapeutic effect of conventional treatment assisted by Danshen Injection in the treatment of oral submucous fibrosis (OSF) and the influence on secreted frizzled related protein 1 (SFRP1). Methods A total of 68 patients with OSF admitted to the First Hospital of Hu'nan University of Chinese Medicine from April 2016 to March 2018 were selected and divided into single drug group (34 cases) and combined group (34 cases) by using random number table method. The single drug group was treated with Triamcinolone Acetonide and the combined group was given Danshen Injection combined with Triamcinolone Acetonide. The mouth opening, oral mucosal impairment area, visual anologue scale (VAS), levels of SFRP1 in gingival crevular fluid and saliva, serum interleukin-6(IL-6), transforming growth factor-β1 (TGF-β1) and clinical effect were compared before and after treatment. Results Before treatment, there were no significant differences in oral mucosal impairment area, VAS score, levels of SFRP1, serum IL-6, TGF-β1 in gingival crevular fluid and saliva between the two groups (P ＞ 0.05); after treatment, the oral mucosal impairment area and VAS score of the combined group were significantly lower than those of the single drug group and mouth opening was higher than that of the single drug group (P ＜ 0.05); levels of SFRP1 in gingival crevicular fluid and saliva in the combined group was higher than that in the single drug group (P ＜ 0.05); serum IL-6 and TGF-β1 in the combined group were lower than those in the single drug group (P ＜ 0.05); the therapeutic effect of the combined group was significantly better than that of the single drug group (P ＜ 0.05). Conclusion The effect of Danshen Injection combined with Triamcinolone Acetonide in the treatment of OSF is better than Triamcinolone Acetonide, which can effectively increase the levels of SFRP1 in gingival crevicular fluid and saliva, and slow down the development of oral submucous fibrosis.

Key words： Danshen Injection Oral submucous fibrosis Secreted frizzled related protein 1 Triamcinolone Acetonide

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	XIAO Yanbo TAN Jin ZHANG Lin LI Qun ZUO Qiaojuan

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XIAO Yanbo TAN Jin ZHANG Lin LI Qun ZUO Qiaojuan. Effect of conventional treatment assisted by Danshen Injection in the treatment of oral submucous fibrosis and its influence on SFRP1 level[J]. 中国医药导报, 2019, 16(25): 79-82.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I25/79

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