噻托溴铵联合沙美特罗/丙酸氟替卡松吸入治疗对慢性阻塞性肺疾病患者肺功能的影响

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Abstract [Abstract] Objective To explore effect of Tiotropium Bromide combined with Salmeterol/Fluticasone Propionate treatment on lung function of COPD patients. Methods clinical data of 75 cases of COPD patients in the Central Hospital of Fushun City from January 2013 to January 2015 were analyzed, According to different treatment method, they were divided into two groups, general treatment group (Spasmolysis and asthma foundation treatment) 35 cases and combined treatment group (Tiotropium Bromide unite Salmeterol/Fluticasone Propionate treatment) 40 cases. The clinical symptom scores, lung function, total effective rate of clinical treatment of two groups of patients before treatment and after treatment were detected. The lung function was tested by lung function instrument. Results There was no statiscal difference of clinical symptom scores [(6.60±2.21) vs (7.14±2.32) scores] between two groups of COPD patients before treatment (t=1.03, P ＞ 0.05). There was no statiscal difference of FEV1 [(1.12±0.67) vs (1.13±0.58) L], FEV1/FVC% [(52.28±3.29)% vs （52.48±3.64）% L], FEV1%Pred [(52.34±4.03)% vs (53.16±3.92)%] between two groups of COPD patients before treatment (t=0.07, 0.25, 0.89, P > 0.05). The clinical symptom score [(4.23±1.62)scores] of combined treatment group COPD patients after treatment was better than general treatment group [(5.66±1.45)scores, t=4.00, P < 0.05]. The FEV1 [(1.96±0.55)L], FEV1/FVC% [(59.92±3.47)%], FEV1%Pred [(63.12±5.24)%] of combined treatment group after treatment were better than general treatment group [(1.54±0.48)L, (56.20±3.24)%, (56.72±4.87)%] (t=3.50, 4.78, 5.45, P < 0.05), the clinical effective rate (100.0%) of combined treatment group COPD patients was higher than general treatment group (74.3%), the difference were statistically significant (χ2=29.49, P < 0.05). Conclusion The clinical effacy of tiotropium bromide combined with salmeterol/ fluticasone propionate treatment on COPD patients is obvious, has good prognosis, which is worthy of clinical application.

Key words： [Key words] Tiotropium Bromide Salmeterol/Fluticasone Propionate COPD Lung function

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	XU Yinghui LI Xiang HAN Yuying

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XU Yinghui LI Xiang HAN Yuying. Effect of Tiotropium Bromide combined with Salmeterol/Fluticasone Propionate treatment on lung function of COPD patients[J]. 中国医药导报, 2016, 13(3): 146-149.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2016/V13/I3/146

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