降钙素基因相关肽的胃黏膜保护机制的研究进展

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Abstract Calcitonin gene-related peptide (CGRP) is a predominant neurotransmitter derived from capsaicin-sensitive sensory nerves, which are widely distributed in the gastrointestinal system. These sensory nerves protect gastric mucosa against damage by sensing various stimuli, and CGRP plays an important role in this process. CGRP protects the gastric mucosa by inhibiting gastric acid secretion, increasing gastric mucosal blood flow, relieving gastrointestinal motility, anti-inflammatory and anti-apoptotic mechanisms. Increasing the release of CGRP is also considered as a potential treatment for gastric diseases. This article focuses on the biological properties of CGRP and the important repairing effect of CGRP on gastric mucosal injury, which is intended to provide new enlightenment for the treatment of gastric ulcer.

Key words： Calcitonin gene-related peptide Capsaicin-sensitive sensory nerves Gastric mucosal protection Gastric ulcer

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	LUO Shuanghui LIU Wei ZENG Zhiqin HU Chupeng XU Ningyin HUANG An XI Tao XING Yingying

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LUO Shuanghui LIU Wei ZENG Zhiqin HU Chupeng XU Ningyin HUANG An XI Tao XING Yingying. Research progress on gastric mucosal protection mechanism of calcitonin gene-related peptide[J]. 中国医药导报, 2019, 16(25): 41-44,56.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I25/41

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