Abstract Breast cancer is one of the most common malignant tumors in women. Despite the continuous improvement of current diagnosis and treatment technologies and the increasing proportion of early breast cancer in the new cases of breast cancer, local advanced breast cancer (LABC) is still a prominent clinical problem. LABC has become an important factor affecting the treatment effect of breast cancer due to its low overall survival rate, high recurrence rate and distant metastasis rate. Radiotherapy, including preoperative radiotherapy and postoperative radiotherapy, is currently recognized as an effective treatment that can control the metastasis of breast cancer and improve the survival rate of breast cancer patients. However, there are few clinical studies on preoperative radiotherapy. Preoperative radiotherapy is known to reduce tumor diameter, make tumor tissue and surrounding normal tissue fibrosis and prevent intraoperative tumor spread, which can improve the quality of life of LABC patients. In this paper, the research status of LABC and preoperative radiotherapy of LABC are reviewed.
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