血清缺氧诱导因子-1α、髓鞘碱性蛋白和超敏C反应蛋白在糖尿病周围神经病变中的变化及临床意义

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Abstract Objective To detect the levels of serum hypoxia inducible factor-1α (HIF-1α), myelin basic protein (MBP), high sensitive C reactive protein (hs-CRP) and oxidative stress response in patients with diabetic peripheral neuropathy, and analyze the correlation among them. Methods 90 cases of patients with diabetic peripheral neuropathy treated in the Fifth Atfiliated Hospital of Xinjiang Medical University ("our hospital" for short) from July 2015 to July 2016 were selected as the study group. 80 healthy cases matched by age and gender in our hospital at the same time were selected as the control group. General biochemical indexes, levls of serum HIF-1α, MBP, hs-CRP, oxidative stress levels of super oxide dismutase (SOD), reduced glutathione (GSH), and malonaldehyde (MDA) were detected and compared between the two gorups. The multivariate Logistic regression analysis was used to analyze the influence factors of diabetic peripheral neuropathy. Spearman correlation test was used to analyze the correlation among serum HIF-1α, MBP, hs-CRP and SOD, GSH, MDA in the study group. Results The levels of total cholesterol (TC), triglyceride (TG), fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) in the study group were significantly higher than those in the control group (P < 0.05). The levers of serum HIF-1α, MBP and hs-CRP in the study group were significantly higher than those in the control group, the differences were statistically significant (P < 0.05). The levels of serum SOD and GSH in the study group were significantly lower than those in the control group (P < 0.05), and the serum MDA level in the study group was significantly higher than that in the control group (P < 0.05). The multivariate Logistic regression analysis showed that age, duration of diabetes, TC, TG, FPG, HbA1c, FINS, MBP, hs-CRP, HIF-1α, MDA were independent risk factors of diabetic peripheral neuropathy (P < 0.05), SOD and GSH were protective factors of diabetic peripheral neuropathy (P < 0.05). Spearman correlation analysis showed that serum HIF-1α, MBP and hs-CRP in study group were positively correlated with MDA level (r=0.547, 0.624, 0.685, P < 0.05), and which were negatively correlated with SOD and GSH levels (r=-0.565, -0.583, -0.592, r=-0.492, -0.551, -0.572, P < 0.05). Conclusion The higher levels of serum HIF-1α, MBP and hs-CRP levels and oxidative stress are involved in the occurrence and development of diabetic peripheral neuropathy, which can be taken as clinical diagnostic bio-markers in patients with diabetic peripheral neuropathy, and provide theoretical basises for clinical intervention.

Key words： Diabetic peripheral neuropathy HIF-1α MBP hs-CRP Oxidative stress

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	ZHANG Li LUO Li LU Chunhui ZHANG Jie WANG Minzhe

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ZHANG Li LUO Li LU Chunhui ZHANG Jie WANG Minzhe. Changes and clinical significance of HIF-1α, MBP and hs-CRP in patients with diabetic peripheral neuropathy[J]. 中国医药导报, 2017, 14(15): 174-178.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I15/174

[1] Inceu G，Demea H，Veresiu IA. Corneal Confocal Microscopy-A Novel，Noninvasive Method to Assess Diabetic Peripheral Neuropathy [J]. Romanian J Diabet Nutr Metab Dis，2016， 21（4）：319-326.
[2] Trippe BS，Barrentine LW，Curole MV，et al. Nutritional management of patients with diabetic peripheral neuropathy with metanx： results of a real-world patient experience trial [J]. Curr Med Res Opin，2016，32（2）：1-28.
[3] Yu S，Chen Y，Hou X，et al. Serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes：a systematic review and meta-analysis [J]. Mol Neurobiol，2016， 53（2）：1045-1051.
[4] Hewston P，Deshpande N. Falls and balance impairments in older adults with type 2 diabetes： thinking beyond diabetic peripheral neuropathy [J]. Can J Diabetes，2016，40（1）：6-9.
[5] Ozuguz U，Oruc S，Ulu MS，et al. Does vitamin d have any role in the improvement of diabetic peripheral neuropathy in type 1 diabetic patients? [J]. J Endocrinol Invest，2016， 39（12）：1411-1417.
[6] Adams AS，Parker MM，Moffet HH，et al. Communication barriers and the clinical recognition of diabetic peripheral neuropathy in a diverse cohort of adults： the distance study [J]. J Health Commun，2016，21（5）：544-553.
[7] Handsaker JC，Brown SJ，Bowling FL，et al. People with diabetic peripheral neuropathy display a decreased stepping accuracy during walking：potential implications for risk of tripping [J]. Diabet Med，2016，33（5）：644-649.
[8] Roy RP，Ghosh K，Ghosh M，et al. Study of vitamin b12deficiency and peripheral neuropathy in metformin-treated early type 2 diabetes mellitus [J]. Indian J Endocrinol Metab，2016，20（5）：631-637.
[9] Vas PR，Edmonds ME. Early recognition of diabetic peripheral neuropathy and the need for one-stop microvascular assessment [J]. Lancet Diabetes Endocrinol，2016，4（9）：723-725.
[10] Zhang X，Hu Y，Shen J，et al. Low levels of ficolin-3 are associated with diabetic peripheral neuropathy [J]. Acta Diabetol，2016，53（2）：295-302.
[11] Baltzis D，Roustit M，Grammatikopoulou MG，et al. Diabetic peripheral neuropathy as a predictor of asymptomatic myocardial ischemia in type 2 diabetes mellitus： a cross-sectional study [J]. Adv Ther，2016，33（10）：1-8.
[12] Won JC，Park TS. Recent advances in diagnostic strategies for diabetic peripheral neuropathy [J]. Endocrinol Metab （Seoul），2016，31（2）：230-238.
[13] Jin HY，Lee KA，Park TS. The impact of glycemic variability on diabetic peripheral neuropathy [J]. Endocrine，2016，53（3）：1-6.
[14] Dobrowsky RT. Targeting the diabetic chaperome to improve peripheral neuropathy [J]. Curr Diab Rep，2016，16（8）：1-10.
[15] 王瑞，芦夏，由天辉，等.广州市正常体检人群高血压前期及其合并的糖脂代谢异常情况[J].广东医学，2015， 36（13）：2083-2087.
[16] Chatzikosma G，Pafili K，Demetriou M，et al. Evaluation of sural nerve automated nerve conduction study in the diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus [J]. Arch Med Sci，2016，12（2）：390-393.
[17] Lenherr SM，Clemens JQ，Braffett BH，et al. Glycaemic control and risk of incident urinary incontinence in women with type 1 diabetes：results from the diabetes control and complications trial and epidemiology of diabetes interventions and complications（dcct/edic）study [J]. Diabet Med，2016，33（11）：1528-1535.
[18] Duksal T，Tiftikcioglu BI，Bilgin S，et al. Role of inflammation in sensory neuropathy in prediabetes or diabetes [J]. Acta Neurol Scand，2016，133（5）：384-390.
[19] Srinivasan S，Pritchard N，Sampson GP，et al . Focal loss volume of ganglion cell complex in diabetic neuropathy [J]. Clin Exp Optom，2016，99（6）：526-534.
[20] Chen J，Li L. Validation of neuropathic pain assessment tools among chinese patients with painful diabetic peripheral neuropathy [J]. Int J Nurs Sci，2016，3（2）：139-145.