重症肺炎患儿肺泡动脉氧分压差及D-二聚体与肺功能的相关性

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Abstract Objective To investigate the relationship between alveolar arterial oxygen partial pressure (PA-aO2) or plasma D-dimer (DD) and pulmonary function in children with severe pneumonia. Methods From January 2011 to December 2016, in Third Hospital of Xingtai, 95 children with severe pneumonia were selected as the observation group, and 50 healthy children were selected as control group at the same period. The first second forced expiratory volume (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and maximal midexpiratory flow (MMF), PA-aO2 and plasma DD in health children and children with severe pneumonia in acute phase and 3, 6 months after discharge were monitored, and the correlation between PA-aO2, DD and the changes of pulmonary function indexes were analyzed. Results The pulmonary function indexes (FEV1, FVC, PEF, MMF) in children with severe pneumonia were significantly lower than the control group, the differences were statistically significant (P < 0.01), and the levels of PA-aO2 and DD was significantly higher than the control group, the differences were statistically significant (P < 0.01). The FEV1, FVC, PEF and MMF in children at 3, 6 months after discharge were higher than those in the acute phase, the differences were statistically significant (P < 0.01), PA-aO2 and plasma DD were lower than those in the acute stage, the differences were statistically significant (P < 0.01). The PA-aO2 in children with severe pneumonia showed a negatively correlation with FVC, FEV1, PEF and MMF (r = -0.459, -0.476, -0.475, -0.689, P < 0.05), and the DD level also showed a negatively correlation with FVC, FEV1, PEF and MMF (r = -0.481, -0.384, -0.463, -0.693, P < 0.05). Conclusion PA-aO2 and DD in children with severe pneumonia has significant correlation with the degree of pulmonary function impairment. It has important value in the assessment, treatment and prognosis of children with severe pneumonia.

Key words： Severe pneumonia Children Alveolar arterial oxygen partial pressure difference D-dimer Pulmonary function

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GUO Yijun HAO Xianwei▲. Correlation between alveolar arterial oxygen pressure or D-dimer and pulmonary function in children with severe pneumonia[J]. 中国医药导报, 2017, 14(15): 113-116.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I15/113

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